Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 60 findings · 21 reviews · Pregnancy and Childbirth

No studies found 3 · 5%GRADE not reported 4 · 6.7%Very low 4 · 6.7%Low 24 · 40%Moderate 15 · 25%High 10 · 16.7%

Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D)

Preterm birth · pregnant women and their infants..

Vitamin D + calcium + other vitamins and minerals showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with calcium + other vitamins and minerals (but no vitamin D) (low certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Preterm birth · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with placebo, no placebo or other supplements (high certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (< 37 weeks' gestation) · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in preterm birth (< 37 weeks' gestation) (high certainty).

1 finding from 1 review

Group antenatal care vs individual antenatal care (adjusted data)

Gestational age (preterm birth < 37 weeks) · pregnant women accessing prenatal care

Group antenatal care showed no clear difference in preterm birth (gestational age at time of birth less than 37 weeks'… compared with individual antenatal care (adjusted data) (moderate certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Chronic lung disease · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in chronic lung disease (CLD) ‐ oxygen supplement at 36 weeks… compared with ECC (subgroup analysis by gestation) (high certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Chronic lung disease · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in chronic lung disease (CLD) ‐ oxygen supplement at 36 weeks… compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Chronic lung disease · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in chronic lung disease (CLD) ‐ oxygen supplement at 36 weeks… compared with UCM (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death (fetal, neonatal, or later (up to 2 years' corrected age))** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death (fetal, neonatal, or later (up to 2 years' corrected age))** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death or cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death or cerebral palsy (up to school age)** compared with placebo (outcomes (low certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Major neurodevelopmental disability at childhood · women at risk of preterm birth (< 34 weeks' gestation)

It is very uncertain whether magnesium sulphate changes major neurodevelopmental disability (school age)** compared with placebo (outcomes (very low certainty).

1 finding from 1 review