Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 68 findings · 15 reviews

No studies found 11 · 16.2%GRADE not reported 2 · 2.9%Very low 16 · 23.5%Low 14 · 20.6%Moderate 14 · 20.6%High 11 · 16.2%

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

Neurologic injury: all available studies · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in neurologic injury: all available studies compared with conventional care (moderate certainty).

1 finding from 1 review

Inhaled NO vs control

Mortality before hospital discharge · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry before 3 days based on… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Intraventricular haemorrhage, Papile grade 3/4 · respiratory failure in preterm infants

Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Neurodevelopmental disability · respiratory failure in preterm infants

Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry before 3 days… compared with control (moderate certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Inadequate oxygenation (SaO₂ < 90% on peripheral oxygen saturation) · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

It is very uncertain whether proSeal changes inadequate oxygenation (SaO₂ < 90% on peripheral oxygen saturation) compared with classic laryngeal mask airway (LMA) (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for tracheal re‐intubation for postoperative stridor (defined as the need to re‐intubate to assure oxygenation to deal with postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for tracheal re‐intubation for postoperative stridor (defined… compared with uncuffed tubes (very low certainty).

1 finding from 1 review