Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 53 findings · 27 reviews · Airways

No studies found 5 · 9.4%GRADE not reported 1 · 1.9%Very low 4 · 7.5%Low 18 · 34%Moderate 21 · 39.6%High 4 · 7.5%

Anti‐leukotrienes & ICS vs same‐dose ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · children with asthma

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with same dose ICS (low certainty).

1 finding from 1 review

Anti‐leukotrienes & ICS vs ICS dose increase

Number of participants experiencing one or more episode requiring treatment with oral steroids · children with asthma

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with higher dose ICS (low certainty).

1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants requiring oral corticosteroids over the study period · Adults from minority groups with doctor diagnosed asthma

It is very uncertain whether the intervention changes number of participants requiring oral corticosteroids over the study… (very low certainty).

1 finding from 1 review

Intervention not reported

Exacerbations requiring oral corticosteroids 7.3‐month · people with asthma

The intervention showed no clear difference in exacerbations requiring oral corticosteroids 7.3‐month (low certainty).

1 finding from 1 review

Intervention not reported

Exacerbations requiring oral corticosteroids3 months · adults or children with asthma

The intervention showed no clear difference in exacerbations requiring oral corticosteroids3 months (low certainty).

1 finding from 1 review

Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with exercise‐induced asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Exacerbations requiring a course of oral corticosteroids · children and adolescents aged 18 years and under studies with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Asthma relapse1at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in asthma relapse1at 20 to 24 days compared with oral corticosteroid (high certainty).

1 finding from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Hoarseness at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in hoarseness at 20 to 24 days compared with oral corticosteroid (moderate certainty).

1 finding from 1 review