Cochrane · systematic review · CD011032
Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults
Chong, J, Haran, C, Chauhan, BF, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 7.7%Low 6 · 46.2%Moderate 6 · 46.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intermittent ICS versus placebo for children and adults with persistent asthma
Population: School‐aged children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations requiring oral corticosteroids ‐ School‐age children Intermittent ICS vs placebo | OR 0.57 [0.29, 1.12] | 1 study · 145 participants | Low Downgraded: imprecision |
Exacerbations requiring oral corticosteroids ‐ adults Intermittent ICS vs placebo | OR 0.1 [0.01, 1.95] | 1 study · 240 participants | Low Downgraded: imprecision |
Serious adverse events Intermittent ICS vs placebo | OR 1 [0.14, 7.25] | 2 studies · 385 participants | Moderate Downgraded: imprecision |
Day time asthma score Mean difference Intermittent ICS vs placebo | no estimate extracted | 1 study · 240 participants | Moderate Downgraded: imprecision |
Night time asthma score Mean difference Intermittent ICS vs placebo | no estimate extracted | 1 study · 240 participants | Moderate Downgraded: imprecision |
Adverse events Intermittent ICS vs placebo | OR 2.9 [0.12, 71.96] | 1 study · 243 participants | Low Downgraded: imprecision |
Intermittent ICS versus placebo for preschool children with wheeze
Population: Preschool children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations requiring oral corticosteroids Intermittent ICS vs placebo | OR 0.48 [0.31, 0.73] | 4 studies · 490 participants | Moderate |
Serious adverse events Intermittent ICS vs placebo | OR 0.42 [0.17, 1.02] | 3 studies · 439 participants | Low Downgraded: imprecision |
Hospitalisations Intermittent ICS vs placebo | OR 0.73 [0.23, 2.29] | 3 studies · 327 participants | Very low Downgraded: imprecision |
Quality of Life PedsQL total score Intermittent ICS vs placebo | no estimate extracted | 1 study · 143 participants | Low Downgraded: imprecision |
Day time asthma score Standardised mean difference Intermittent ICS vs placebo | no estimate extracted | 3 studies · 364 participants | Moderate |
Night time asthma score Standardised mean difference Intermittent ICS vs placebo | no estimate extracted | 3 studies · 364 participants | Moderate |
Adverse events Intermittent ICS vs placebo | OR 0.86 [0.42, 1.75] | 1 study · 166 participants | Low Downgraded: imprecision |