Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 68 findings · 19 reviews · Pregnancy and Childbirth

No studies found 11 · 16.2%GRADE not reported 6 · 8.8%Very low 21 · 30.9%Low 23 · 33.8%Moderate 6 · 8.8%High 1 · 1.5%

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Number of women with total blood loss 1000 mL or more after randomisation · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Maternal blood loss of 500 mL or greater · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Non‐exclusive breastfeeding (foods) vs exclusive breastfeeding

“Food allergy” to 1 or more foods between 1 to 3 years of age · healthy breastfeeding full‐term infants

Non‐exclusive breastfeeding (foods) showed no clear difference in “Food allergy” to 1 or more foods between 1 to 3 years of age compared with exclusive breastfeeding (moderate certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron and folic acid probably leads to lower maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with same supplements without iron nor folic acid (no iron nor folic acid… (moderate certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Iron deficiency at term (as defined by trialists, based on any indicator of iron status at 37 wk gestation or more) · pregnant women

(Maternal outcomes) Any supplements containing iron and folic acid may leads to lower maternal iron deficiency at term (as defined by trialists, based on… compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron may leads to lower maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Iron deficiency at term (as defined by trialists, based on any indicator of iron status at 37 wk gestation or more) · pregnant women

(Maternal outcomes) Any supplements containing iron may leads to lower maternal iron deficiency at term (as defined by as defined by… compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Specialised antenatal clinics vs usual care

Postnatal depression · Women with a multiple pregnancy

It is very uncertain whether specialised antenatal clinics changes postnatal depression (6 months' postpartum). EPDS score 13 or more. compared with standard care (very low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Major neonatal morbidity · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in major neonatal morbidity one or more of the following: hypoxic… compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Significant maternal morbidity one or more of the following: significant postpartum haemorrhage requiring blood transfusion; maternal admission to intensive care unit; uterine rupture; hysterectomy · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in significant maternal morbidity one or more of the following:… compared with expectant management (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review