Cochrane · systematic review · CD001808
Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage
Salati, JA, Leathersich, SJ, Williams, MJ, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
13
No studies
8
Included studies
NR
No studies 8 · 38.1%Ungraded 0 · 0%Very low 4 · 19%Low 5 · 23.8%Moderate 4 · 19%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oxytocin compared to no uterotonics or placebo for the third stage of labour to prevent postpartum haemorrhage
Population: women in the third stage of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood loss 500 mL or more after delivery Oxytocin vs no uterotonics or placebo | RR 0.51 [0.37, 0.72] | 6 studies · 4162 participants | Low Downgraded: risk of bias |
Need for additional uterotonics Oxytocin vs no uterotonics or placebo | RR 0.54 [0.36, 0.8] | 4 studies · 3135 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Maternal all‐cause mortality Oxytocin vs no uterotonics or placebo | no estimate extracted | NR | No studies |
Blood loss 1000 mL or more after delivery Oxytocin vs no uterotonics or placebo | RR 0.59 [0.42, 0.83] | 5 studies · 4123 participants | Low Downgraded: risk of bias |
Blood transfusion Oxytocin vs no uterotonics or placebo | RR 0.88 [0.44, 1.78] | 3 studies · 3081 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Third stage greater than 30 minutes Oxytocin vs no uterotonics or placebo | RR 2.55 [0.88, 7.44] | 1 study · 1947 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Diastolic blood pressure > 100 mm Hg between delivery of the baby and discharge from the labour ward Oxytocin vs no uterotonics or placebo | no estimate extracted | NR | No studies |
Oxytocin compared to ergot alkaloids for the third stage of labour to prevent postpartum haemorrhage
Population: women in the third stage of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood loss 500 mL or more after delivery Oxytocin vs ergot alkaloids | RR 0.84 [0.56, 1.25] | 10 studies · 3082 participants | Very low Downgraded: risk of bias |
Need for additional uterotonics Oxytocin vs ergot alkaloids | RR 0.89 [0.43, 1.81] | 8 studies · 2178 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Maternal all‐cause mortality Oxytocin vs ergot alkaloids | no estimate extracted | NR | No studies |
Blood loss 1000 mL or more after delivery Oxytocin vs ergot alkaloids | RR 1.13 [0.63, 2.01] | 3 studies · 1577 participants | Very low Downgraded: risk of bias |
Blood transfusion Oxytocin vs ergot alkaloids | RR 1.37 [0.34, 5.51] | 7 studies · 1578 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Third stage > 30 minutes Oxytocin vs ergot alkaloids | RR 4.69 [1.63, 13.45] | 2 studies · 450 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Diastolic blood pressure > 100 mm Hg between delivery of the baby and discharge from the labour ward Oxytocin vs ergot alkaloids | RR 0.28 [0.04, 2.05] | 3 studies · 960 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Oxytocin + ergometrine compared to ergot alkaloids for the third stage of labour to prevent postpartum haemorrhage
Population: women in the third stage of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood loss 500 mL or more after delivery Oxytocin + ergometrine vs ergot alkaloids | RR 0.44 [0.2, 0.94] | 3 studies · 1168 participants | Low Downgraded: risk of bias |
Need for additional uterotonics Oxytocin + ergometrine vs ergot alkaloids | no estimate extracted | NR | No studies |
Maternal all‐cause mortality Oxytocin + ergometrine vs ergot alkaloids | no estimate extracted | 1 study · 807 participants | Moderate Downgraded: risk of bias, imprecision |
Blood loss 1000 mL or more after delivery Oxytocin + ergometrine vs ergot alkaloids | no estimate extracted | NR | No studies |
Blood transfusion Oxytocin + ergometrine vs ergot alkaloids | no estimate extracted | NR | No studies |
Third stage > 30 minutes Oxytocin + ergometrine vs ergot alkaloids | no estimate extracted | NR | No studies |
Diastolic blood pressure > 100 mm Hg between delivery of the baby and discharge from the labour ward Oxytocin + ergometrine vs ergot alkaloids | no estimate extracted | NR | No studies |