Neonatal colonization with GBS within the first seven days of life · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes neonatal colonization with GBS within the first seven days of life compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Neonatal mortality due to early‐onset GBS infection · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
1 finding from 1 review
Adverse (mild) effects in the mother · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes adverse (mild) effects in the mother compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Adverse (mild) effects in the neonate · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
1 finding from 1 review
Surgical site infection · women undergoing caesarean section
Chlorhexidine gluconate probably leads to lower surgical site infection compared with povidone iodine (moderate certainty).
1 finding from 1 review
Endometritis · women undergoing caesarean section
Chlorhexidine gluconate showed no clear difference in endometritis compared with povidone iodine (low certainty).
1 finding from 1 review
Length of stay · women undergoing caesarean section
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events (maternal) ‐ skin irritation or allergic skin reaction · women undergoing caesarean section
It is very uncertain whether chlorhexidine gluconate changes adverse events (maternal) ‐ skin irritation or allergic skin reaction compared with povidone iodine (very low certainty).
1 finding from 1 review
Hospital‐acquired infections Data collected during ICU stay · critically ill patients
1 finding from 1 review
Mortality (ICU, hospital) (days) · critically ill patients
It is very uncertain whether bathing of the critically ill with chlorhexidine changes mortality Data collected (where reported) in hospital, in the ICU,… compared with bathing with soap and water or non‐antimicrobial washcloths (very low certainty).
1 finding from 1 review
Duration of ICU stay · critically ill patients
1 finding from 1 review
Surgical site infection · surgical patients
Preoperative showering with chlorhexidine 4% showed no clear difference in surgical site infection compared with placebo (high certainty).
1 finding from 1 review
Allergic reaction · surgical patients
Preoperative showering with chlorhexidine 4% showed no clear difference in allergic reaction compared with placebo (moderate certainty).
1 finding from 1 review
Sepsis without a source · newborn infants with central venous catheters
Chlorhexidine dressing following alcohol cleansing showed no clear difference in sepsis without a source compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).
1 finding from 1 review
Catheter‐related blood stream infection · newborn infants with central venous catheters
Chlorhexidine dressing following alcohol cleansing showed no clear difference in catheter‐related blood stream infection compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).
1 finding from 1 review
Catheter colonisation · newborn infants with central venous catheters
Chlorhexidine dressing following alcohol cleansing probably leads to lower catheter colonisation compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).
1 finding from 1 review
Adverse effects: contact dermatitis · newborn infants with central venous catheters
Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).
1 finding from 1 review
Catheter‐related blood stream infection · patients with CVCs
Chlorhexidine gluconate‐impregnated (CGI) dressing showed no clear difference in catheter‐related blood stream infection compared with SPU dressings (moderate certainty).
1 finding from 1 review
Catheter tip colonisation · patients with CVCs
Chlorhexidine gluconate‐impregnated (CGI) dressing probably leads to lower catheter tip colonisation: compared with SPU dressings (moderate certainty).
1 finding from 1 review
Adverse events requiring hospitalisation (SAE) · Neonates and caregivers
It is very uncertain whether four per cent chlorhexidine + hand hygiene promotion changes adverse events requiring hospitalisation (SAE) compared with usual care (very low certainty).
1 finding from 1 review