Findings

What do systematic reviews say?

194 questions · 239 findings · 32 reviews · Headline outcomes only

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No studies found 46 · 19.2%GRADE not reported 18 · 7.5%Very low 36 · 15.1%Low 56 · 23.4%Moderate 58 · 24.3%High 25 · 10.5%

Continuous glucose monitoring system vs intermittent modalities

Cerebral palsy ‐ not reported · infants at risk of hypoglycaemia or hyperglycaemia

The review found no eligible studies for this question.

1 finding from 1 review

Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Cerebral palsy at 18 to 24 months' corrected age · preterm infants with low birth weight

The intervention showed no clear difference in cerebral palsy at 18 to 24 months' corrected age (high certainty).

1 finding from 1 review

Early erythropoiesis‐stimulating agents in preterm or low birth weight infants 2020 · Cochrane Headline outcomes only
RR 0.72 [0.46, 1.13]
6 studies · 1172 participants
High

Moderate vs low protein concentration of human milk fortifier

Cerebral palsy · preterm infants

1 finding from 1 review

Comparison of different protein concentrations of human milk fortifier for promoting growth and neurological… 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

High vs moderate protein concentration of human milk fortifier

Cerebral palsy · promoting short‐term growth of preterm infants

1 finding from 1 review

Comparison of different protein concentrations of human milk fortifier for promoting growth and neurological… 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Cerebral palsy in infancy · late preterm or term newborns with hypoxic‐ischaemic encephalopathy

The review found no eligible studies for this question.

1 finding from 1 review

Xenon as an adjuvant to therapeutic hypothermia in near‐term and term newborns with hypoxic‐ischaemic encephalopathy 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous CTG vs intermittent auscultation

Cerebral palsy · Pregnant women undergoing fetal assessment during labour

Continuous CTG showed no clear difference in cerebral palsy compared with intermittent auscultation (low certainty).

1 finding from 1 review

Continuous cardiotocography (CTG) as a form of electronic fetal monitoring (EFM) for fetal assessment during labour 2017 · Cochrane Headline outcomes only
RR 1.75 [0.84, 3.63]
2 studies · 13252 participants
Low

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Doppler vs routine Pinard (outcomes

Cerebral palsy · women in established labour and their babies.

1 finding from 1 review

Intermittent auscultation (IA) of fetal heart rate in labour for fetal well‐being 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intensive Pinard vs routine Pinard (outcomes

Cerebral palsy · women in established labour and their babies.

1 finding from 1 review

Intermittent auscultation (IA) of fetal heart rate in labour for fetal well‐being 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intermittent electronic fetal monitoring (CTG) vs routine Pinard (outcomes

Cerebral palsy · women in established labour and their babies.

1 finding from 1 review

Intermittent auscultation (IA) of fetal heart rate in labour for fetal well‐being 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Barbiturate treatment vs placebo or no treatment

Cerebral palsy · infants with perinatal asphyxia

It is very uncertain whether barbiturate treatment changes cerebral palsy compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia 2016 · Cochrane Headline outcomes only
RR 0.58 [0.19, 1.7]
2 studies · 69 participants
Very low

Intervention not reported

Cerebral Palsy · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
37 participants
Low

Universal screening vs No screening

Neurosensory disability · women during pregnancy

Universal screening showed no clear difference in neurosensory disability (any of cerebral palsy, blindness, deafness,… compared with no screening (moderate certainty).

1 finding from 1 review

Screening and subsequent management for thyroid dysfunction pre‐pregnancy and during pregnancy for improving maternal… 2015 · Cochrane Headline outcomes only
RR 0.85 [0.6, 1.22]
1 study · 794 participants
Moderate

Universal screening vs case finding

Neurosensory disability · women during pregnancy

The review found no eligible studies for this question.

1 finding from 1 review

Screening and subsequent management for thyroid dysfunction pre‐pregnancy and during pregnancy for improving maternal… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Cerebral palsy · preterm or low birth weight infants

The intervention showed no clear difference in cerebral palsy (moderate certainty).

1 finding from 1 review

Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants 2012 · Cochrane Headline outcomes only
RR 0.96 [0.5, 1.85]
2 studies · 756 participants
Moderate

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

BMD: % change in BMD at the lumbar spine · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

Change in volumetric BMD of distal radius or tibia · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

Change in fracture frequency · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

Number of participants reporting an adverse event · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
GRADE not reported

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

Change in NTX (assessed 4 to 6 months post‐intervention) · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 32 participants
Very low

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

Change in BAP (assessed 4 to 6 months post‐intervention) · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 32 participants
Very low