Cochrane · systematic review · CD007090
Comparison of different protein concentrations of human milk fortifier for promoting growth and neurological development in preterm infants
Gao, C, Miller, J, Collins, CT, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 6 · 50%Very low 4 · 33.3%Low 1 · 8.3%Moderate 1 · 8.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
High compared to moderate protein concentration of human milk fortifier for promoting growth and neurological development in preterm infants
Population: promoting growth and neurological development in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain (g/kg/day) until the end of the intervention High vs moderate protein concentration of human milk fortifier | no estimate extracted | 6 studies · 606 participants | Moderate Downgraded: risk of bias, imprecision |
Length gain (cm/week) until the end of the intervention High vs moderate protein concentration of human milk fortifier | no estimate extracted | 5 studies · 547 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Head circumference gain (cm/week) until the end of the intervention High vs moderate protein concentration of human milk fortifier | no estimate extracted | 5 studies · 549 participants | Very low Downgraded: risk of bias, imprecision |
Cerebral palsy at ≥ 18 months High vs moderate protein concentration of human milk fortifier | no estimate extracted | 0 studies · 0 participants | Ungraded |
Developmental delay at ≥ 18 months High vs moderate protein concentration of human milk fortifier | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mortality during intervention period High vs moderate protein concentration of human milk fortifier | no estimate extracted | 1 study · 45 participants | Ungraded |
Moderate compared to low protein concentration of human milk fortifier for promoting growth and neurological development in preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain (g/kg/day) until the end of the intervention Moderate vs low protein concentration of human milk fortifier | no estimate extracted | 2 studies · 176 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Length gain (cm/week) until the end of the intervention Moderate vs low protein concentration of human milk fortifier | no estimate extracted | 3 studies · 217 participants | Low Downgraded: risk of bias, imprecision |
Head circumference gain (cm/week) until the end of the intervention Moderate vs low protein concentration of human milk fortifier | no estimate extracted | 3 studies · 217 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cerebral palsy at ≥ 18 months Moderate vs low protein concentration of human milk fortifier | no estimate extracted | 0 studies · 0 participants | Ungraded |
Developmental delay at ≥ 18 months Moderate vs low protein concentration of human milk fortifier | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mortality during the intervention period Moderate vs low protein concentration of human milk fortifier | RR 0.48 [0.05, 5.17] | 1 study · 112 participants | Ungraded |