Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

101 questions · 119 findings · 15 reviews · Headline outcomes only

No studies found 22 · 18.5%GRADE not reported 16 · 13.4%Very low 45 · 37.8%Low 31 · 26.1%Moderate 5 · 4.2%High 0 · 0%

Bilateral subtotal thyroidectomy vs the Dunhill procedure

Permanent recurrent laryngeal nerve palsy [patient reported, confirmation by laryngoscopy]

Bilateral subtotal thyroidectomy showed no clear difference in permanent recurrent laryngeal nerve palsy [patient reported,… compared with the Dunhill procedure (low certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Motor alignment at near Change in exotropia control at near fixation, measured from baseline to 3 years using the prism and alternate cover test · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in motor alignment at near Change in exotropia control at near… compared with unilateral lateral rectus recession with medial rectus resection (moderate certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Stereoacuity at near Loss of ≥ 2 octaves near stereoacuity, measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in stereoacuity at near Loss of ≥ 2 octaves near stereoacuity, measured… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Motor alignment at distance Change in exotropia control at near fixation, measured from baseline to 3 years using the prism and alternate cover test · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in motor alignment at distance Change in exotropia control at near… compared with unilateral lateral rectus recession with medial rectus resection (moderate certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged 3 to < 11 years
1 finding from 1 review

Summary of findings: bilateral laminotomy vs conventional laminectomy

VAS back (0 to 10) Unilateral laminotomy compared with conventional laminectomy · patients with lumbar stenosis

Summary of findings: bilateral laminotomy showed no clear difference in VAS back (0 to 10) Unilateral laminotomy compared with conventional… compared with conventional laminectomy (low certainty).

1 finding from 1 review

Summary of findings: bilateral laminotomy vs conventional laminectomy

Incidence of postoperative instability · patients with lumbar stenosis

Summary of findings: bilateral laminotomy may leads to lower incidence of postoperative instability compared with conventional laminectomy (low certainty).

1 finding from 1 review

Summary of findings: bilateral laminotomy vs conventional laminectomy

Incidence of perioperative complications · patients with lumbar stenosis

Summary of findings: bilateral laminotomy showed no clear difference in incidence of perioperative complications compared with conventional laminectomy (low certainty).

1 finding from 1 review

Intervention not reported

Severe hearing loss defined as a threshold of 60 dB or more in the better ear or requiring bilateral hearing aid during the · children with acute bacterial meningitis

The intervention showed no clear difference in severe hearing loss defined as a threshold of 60 dB or more in the… (low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): bilateral bundle branch block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): bilateral bundle branch… compared with propafenone (very low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Major VTE events bilateral ascending venography1 · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events bilateral ascending venography1 compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Major VTE events in TKR combined doses bilateral ascending venography · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events in TKR combined doses bilateral ascending venography compared with vitamin K antagonists (low certainty).

1 finding from 1 review