Cochrane · systematic review · CD010576
Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy
Liu, ZW, Masterson, L, Fish, B, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
12
No studies
6
Included studies
NR
No studies 6 · 28.6%Ungraded 3 · 14.3%Very low 0 · 0%Low 10 · 47.6%Moderate 2 · 9.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Total thyroidectomy compared to subtotal thyroidectomy for Graves disease and Graves' opthalmopathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Rate of recurrent hyperthyroidism [measured by thyroid function tests] Total thyroidectomy vs subtotal thyroidectomy | OR 0.14 [0.04, 0.46] | 2 studies · 350 participants | Moderate Downgraded: risk of bias |
Regression of Graves' ophthalmopathy [ophthalmology assessment] Total thyroidectomy vs subtotal thyroidectomy | OR 1.15 [0.64, 2.08] | 2 studies · 229 participants | Low Downgraded: risk of bias, imprecision |
Permanent recurrent laryngeal nerve palsy [patient reported, confirmation by laryngoscopy] Total thyroidectomy vs subtotal thyroidectomy | OR 1.45 [0.38, 5.59] | 3 studies · 393 participants | Low Downgraded: risk of bias, imprecision |
Permanent hypocalcaemia/hypoparathyroidism [measured by serum calcium levels] Total thyroidectomy vs subtotal thyroidectomy | OR 4.79 [1.36, 16.83] | 3 studies · 393 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality Total thyroidectomy vs subtotal thyroidectomy | no estimate extracted | 1 study · 350 participants | Ungraded |
Health‐related quality of life Total thyroidectomy vs subtotal thyroidectomy | no estimate extracted | NR | No studies |
Socioeconomic effects Total thyroidectomy vs subtotal thyroidectomy | no estimate extracted | NR | No studies |
Total thyroidectomy compared to bilateral subtotal thyroidectomy for Graves disease and Graves' opthalmopathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
R ate of recurrent hyperthyroidism [measured by thyroid function tests] Total thyroidectomy vs bilateral subtotal thyroidectomy | OR 0.13 [0.04, 0.44] | 2 studies · 300 participants | Moderate Downgraded: risk of bias |
Regression of Graves' ophthalmopathy [ophthalmology assessment] Total thyroidectomy vs bilateral subtotal thyroidectomy | OR 1.19 [0.64, 2.21] | 2 studies · 260 participants | Low Downgraded: risk of bias, imprecision |
Permanent recurrent laryngeal nerve palsy [patient reported, confirmation by laryngoscopy] Total thyroidectomy vs bilateral subtotal thyroidectomy | OR 1 [0.14, 7.15] | 2 studies · 300 participants | Low Downgraded: risk of bias, imprecision |
Permanent hypocalcaemia/hypoparathyroidism [measured by serum calcium levels] Total thyroidectomy vs bilateral subtotal thyroidectomy | OR 2.04 [0.53, 7.85] | 2 studies · 300 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality Total thyroidectomy vs bilateral subtotal thyroidectomy | no estimate extracted | 2 studies · 300 participants | Ungraded |
Health‐related quality of life Total thyroidectomy vs bilateral subtotal thyroidectomy | no estimate extracted | NR | No studies |
Socioeconomic effects Total thyroidectomy vs bilateral subtotal thyroidectomy | no estimate extracted | NR | No studies |
Bilateral subtotal thyroidectomy compared to the Dunhill procedure for Graves disease and Graves' opthalmopathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
R ate of recurrent hyperthyroidism [measured by thyroid function tests] Bilateral subtotal thyroidectomy vs the Dunhill procedure | OR 2.73 [1.28, 5.85] | 3 studies · 592 participants | Low Downgraded: risk of bias, imprecision |
Regression of Graves' ophthalmopathy [ophthalmology assessment] Bilateral subtotal thyroidectomy vs the Dunhill procedure | OR 0.78 [0.32, 1.92] | 2 studies · 90 participants | Low Downgraded: risk of bias, imprecision |
Permanent recurrent laryngeal nerve palsy [patient reported, confirmation by laryngoscopy] Bilateral subtotal thyroidectomy vs the Dunhill procedure | OR 0.14 [0, 6.82] | 3 studies · 592 participants | Low Downgraded: risk of bias, imprecision |
Permanent hypocalcaemia/hypoparathyroidism [measured by serum calcium levels] Bilateral subtotal thyroidectomy vs the Dunhill procedure | OR 1.9 [0.47, 7.71] | 3 studies · 592 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality Bilateral subtotal thyroidectomy vs the Dunhill procedure | no estimate extracted | 3 studies · 642 participants | Ungraded |
Health‐related quality of life Bilateral subtotal thyroidectomy vs the Dunhill procedure | no estimate extracted | NR | No studies |
Socioeconomic effects Bilateral subtotal thyroidectomy vs the Dunhill procedure | no estimate extracted | NR | No studies |