Cochrane · systematic review · CD005981
Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous thromboembolism following total hip or knee replacement
Salazar, CA, Malaga, G, Malasquez, G · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 87.5%Moderate 1 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Direct thrombin inhibitors versus low molecular weight heparins
Population: patients with prevention of venous thromboembolism following total hip or knee replacement
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Major VTE events bilateral ascending venography1 Direct thrombin inhibitors vs low molecular weight heparins | OR 0.91 [0.69, 1.19] | 11 studies · 17428 participants | Low Downgraded: inconsistency, publication bias |
All‐cause Mortality events Direct thrombin inhibitors vs low molecular weight heparins | OR 2.06 [1.1, 3.87] | 11 studies · 22065 participants | Moderate Downgraded: publication bias |
Total Bleeding events Direct thrombin inhibitors vs low molecular weight heparins | OR 1.17 [0.98, 1.41] | 11 studies · 22109 participants | Low Downgraded: inconsistency, publication bias |
ALT >3 times the upper normal limit Direct thrombin inhibitors vs low molecular weight heparins | OR 0.41 [0.23, 0.72] | 7 studies · 12580 participants | Low Downgraded: inconsistency, publication bias |
Direct thrombin inhibitors versus vitamin K antagonists
Population: patients with prevention of venous thromboembolism following total hip or knee replacement
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Major VTE events in TKR combined doses bilateral ascending venography Direct thrombin inhibitors vs vitamin K antagonists | OR 0.85 [0.63, 1.15] | 3 studies · 4327 participants | Low Downgraded: publication bias |
All‐cause Mortality events in TKR combined doses Direct thrombin inhibitors vs vitamin K antagonists | OR 1.62 [0.57, 4.58] | 3 studies · 5243 participants | Low Downgraded: publication bias |
Total Bleeding events in TKR combined doses Direct thrombin inhibitors vs vitamin K antagonists | OR 1.26 [0.97, 1.62] | 3 studies · 5259 participants | Low Downgraded: publication bias |
ALT >3 times the upper normal limit at the end of Direct thrombin inhibitors vs vitamin K antagonists | OR 5.61 [1, 31.64] | 2 studies · 4267 participants | Low Downgraded: publication bias |