Cochrane · systematic review · CD013437
Non‐corticosteroid adjuvant therapies for acute bacterial meningitis
Fisher, J, Linder, A, Calevo, MG, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Paracetamol for acute bacterial meningitis
Population: children with acute bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality during the | RR 0.94 [0.81, 1.09] | 3 studies · 1274 participants | Low Downgraded: risk of bias, imprecision |
Any hearing loss defined as 40 dB or more not detected by the better ear during the | RR 1.04 [0.8, 1.34] | 2 studies · 901 participants | Low Downgraded: risk of bias, imprecision |
Any neurological sequelae other than hearing loss defined as health consequences of the infection that involve the central nervous system during the | RR 1.56 [0.98, 2.5] | 3 studies · 1274 participants | Low Downgraded: risk of bias, inconsistency |
Adverse events during the | no estimate extracted | 3 studies · 1274 participants | Very low Downgraded: risk of bias, imprecision |
Severe hearing loss defined as a threshold of 60 dB or more in the better ear or requiring bilateral hearing aid during the | RR 0.96 [0.67, 1.36] | 2 studies · 901 participants | Low Downgraded: risk of bias, imprecision |
Short‐term neurological sequelae other than hearing loss defined as sequelae present up to 6 weeks after hospital discharge | RR 1.99 [1.4, 2.81] | 2 studies · 1096 participants | Low Downgraded: risk of bias, imprecision |
Long‐term neurological sequelae other than hearing loss defined as sequelae present between 6 weeks after hospital discharge and the last time point reported in the study | RR 2.32 [1.34, 4.04] | 2 studies · 901 participants | Low Downgraded: risk of bias, imprecision |