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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,353 questions in 210 reviews · Neonatal
current versionsNo studies 432 · 18.4%Ungraded 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
High MCT formula vs low MCT formula Weight gain, g/kg/d (high MCT vs low MCT) · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 6 studies · 118 participants | Low |
High MCT formula vs low MCT formula Weight gain, g/d (high MCT vs low MCT) · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 1 study · 18 participants | Very low |
High MCT formula vs low MCT formula Length gain, cm/week (high MCT vs low MCT) · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 3 studies · 61 participants | Very low |
High MCT formula vs low MCT formula Head circumference gain, cm/week (high MCT vs low MCT) · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 3 studies · 61 participants | Low |
High MCT formula vs low MCT formula Skinfold thickness gain (mm/week) (high MCT vs low MCT) · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 2 studies · 32 participants | Very low |
High MCT formula vs low MCT formula Gastrointestinal intolerance · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 5 studies · 145 participants | Very low |
High MCT formula vs low MCT formula NEC · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | 2 studies · 82 participants | Very low |
High MCT formula vs low MCT formula Neurodevelopmental outcomes · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | NR | No studies |
High MCT formula vs low MCT formula Long‐term growth outcomes · promoting short‐term growth of preterm infants High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Time taken to establish full gavage feeding (days) · intermittent bolus gavage tube feeding of preterm and low birth weight infants Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR Feeding intolerance (number of episodes per day) · intermittent bolus gavage tube feeding of preterm and low birth weight infants Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR Respiratory rate (breaths per minute) at completion of feed · intermittent bolus gavage tube feeding of preterm and low birth weight infants Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Very low |
Intervention NR Respiratory rate (breaths per minute) · intermittent bolus gavage tube feeding of preterm and low birth weight infants Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Very low |
Intervention NR Heart rate (beats per minute) at completion of feed · intermittent bolus gavage tube feeding of preterm and low birth weight infants Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Very low |
Intervention NR Heart rate (beats per minute) · intermittent bolus gavage tube feeding of preterm and low birth weight infants Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Very low |
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials) Full breastfeeding compared with not breastfeeding or partial breastfeeding · preterm infants Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane | RR 1.47 [1.19, 1.8] | 6 studies · 1074 participants | Low |
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials) Any breastfeeding (full and partial combined) compared with not breastfeeding · preterm infants Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane | RR 1.11 [1.06, 1.16] | 6 studies · 1138 participants | Moderate |
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials) Length of hospital stay (days) · preterm infants Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane | no estimate extracted | 4 studies · 1004 participants | Low |
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials) Episodes of infection per infant · preterm infants Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane | RR 0.7 [0.35, 1.42] | 3 studies · 500 participants | Low |
Intervention NR Mortality by hospital discharge · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | RR 1 [0.17, 5.77] | 2 studies · 44 participants | Low |
Intervention NR Incidence of bronchopulmonary dysplasia · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | RR 0.25 [0.03, 2.07] | 2 studies · 44 participants | Low |
Intervention NR Duration of supplemental oxygen (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | no estimate extracted | 2 studies · 44 participants | Very low |
Intervention NR Duration of ventilatory support (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | no estimate extracted | 2 studies · 44 participants | Very low |
Intervention NR Duration of continuous positive airway pressure therapy (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Duration of neonatal intensive care unit stay (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Duration of hospital stay (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory… Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane | no estimate extracted | NR | No studies |
Restricted vs standard fluid management Duration of supplemental oxygen therapy (hours) · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 2 studies · 172 participants | Very low |
Restricted vs standard fluid management Incidence of hypernatremia (serum sodium > 145 mEq/L) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | RR 4 [0.46, 34.54] | 1 study · 100 participants | Very low |
Restricted vs standard fluid management Incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | RR 1 [0.15, 6.82] | 2 studies · 164 participants | Very low |
Restricted vs standard fluid management Incidence of endotracheal ventilation (proportions) during hospital stay (for infants on no support or noninvasive support at the time of study entry) · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | RR 0.73 [0.24, 2.23] | 3 studies · 242 participants | Very low |
Restricted vs standard fluid management Incidence of noninvasive (nasal CPAP or nasal ventilation) respiratory support during hospital stay · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | RR 0.4 [0.14, 1.17] | 2 studies · 150 participants | Very low |
Restricted vs standard fluid management Length of hospital stay (in days) · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 1 study · 80 participants | Very low |
Restricted vs standard fluid management Cumulative weight loss at 72 hours of age (%) · late preterm and full‐term infants with transient tachypnea of the newborn Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 2 studies · 156 participants | Very low |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | RR 0.59 [0.48, 0.73] | 10 studies · 1324 participants | Moderate |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Need for intubation within the first 72 hours · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | RR 0.63 [0.54, 0.74] | 12 studies · 1422 participants | Moderate |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Air leak requiring drainage · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | RR 0.58 [0.33, 1.02] | 6 studies · 1036 participants | Low |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Severe intraventricular haemorrhage (grade III or IV) · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | RR 0.63 [0.42, 0.96] | 5 studies · 857 participants | Low |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Death during first hospitalisation (all causes) · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | RR 0.63 [0.47, 0.84] | 11 studies · 1424 participants | Low |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Bronchopulmonary dysplasia (BPD) among survivors at 36 weeks' postmenstrual age · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | RR 0.57 [0.45, 0.74] | 11 studies · 1567 participants | Moderate |
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) Death or survival with neurosensory disability ‐ not reported · preterm infants with or at risk of respiratory distress syndrome Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane | no estimate extracted | NR | No studies |
Salbutamol vs placebo/no treatment Duration of oxygen therapy (hours) · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 4 studies · 338 participants | Very low |
Salbutamol vs placebo/no treatment Need for continuous positive airway pressure (yes/no) · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | RR 0.73 [0.38, 1.39] | 1 study · 46 participants | Very low |
Salbutamol vs placebo/no treatment Need for mechanical ventilation (yes/no) · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | RR 0.6 [0.13, 2.86] | 3 studies · 254 participants | Very low |
Salbutamol vs placebo/no treatment Duration of respiratory support (intermittent positive pressure ventilation or continuous positive airway pressure; hours). · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 2 studies · 228 participants | Very low |
Salbutamol vs placebo/no treatment Duration of hospital stay (days) · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 4 studies · 338 participants | Low |
Salbutamol vs placebo/no treatment Duration of mechanical ventilation (hours) · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | NR | No studies |
Salbutamol vs placebo/no treatment Pneumothorax (yes/no) · patients with transient tachypnea of the newborn Salbutamol for transient tachypnea of the newborn (2021) · Cochrane | no estimate extracted | 1 study · 80 participants | Very low |
Short feeding interval vs long feeding interval Days taken to achieve full feeding · preterm infants < 1500 g Short versus long feeding interval for bolus feedings in very preterm infants (2021) · Cochrane | no estimate extracted | 3 studies · 351 participants | Low |
Short feeding interval vs long feeding interval Days to regain birth weight · preterm infants < 1500 g Short versus long feeding interval for bolus feedings in very preterm infants (2021) · Cochrane | no estimate extracted | 3 studies · 350 participants | Low |
Short feeding interval vs long feeding interval Duration of hospital stay (days) · preterm infants < 1500 g Short versus long feeding interval for bolus feedings in very preterm infants (2021) · Cochrane | no estimate extracted | 2 studies · 207 participants | Very low |