Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

2,353 questions in 210 reviews · Neonatal

current versions
No studies 432 · 18.4%Ungraded 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
High MCT formula vs low MCT formula
Weight gain, g/kg/d (high MCT vs low MCT) · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted6 studies · 118 participantsLow
High MCT formula vs low MCT formula
Weight gain, g/d (high MCT vs low MCT) · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted1 study · 18 participantsVery low
High MCT formula vs low MCT formula
Length gain, cm/week (high MCT vs low MCT) · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted3 studies · 61 participantsVery low
High MCT formula vs low MCT formula
Head circumference gain, cm/week (high MCT vs low MCT) · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted3 studies · 61 participantsLow
High MCT formula vs low MCT formula
Skinfold thickness gain (mm/week) (high MCT vs low MCT) · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted2 studies · 32 participantsVery low
High MCT formula vs low MCT formula
Gastrointestinal intolerance · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted5 studies · 145 participantsVery low
High MCT formula vs low MCT formula
NEC · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extracted2 studies · 82 participantsVery low
High MCT formula vs low MCT formula
Neurodevelopmental outcomes · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extractedNRNo studies
High MCT formula vs low MCT formula
Long‐term growth outcomes · promoting short‐term growth of preterm infants
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Time taken to establish full gavage feeding (days) · intermittent bolus gavage tube feeding of preterm and low birth weight infants
Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane
no estimate extracted0 participantsUngraded
Intervention NR
Feeding intolerance (number of episodes per day) · intermittent bolus gavage tube feeding of preterm and low birth weight infants
Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane
no estimate extracted0 participantsUngraded
Intervention NR
Respiratory rate (breaths per minute) at completion of feed · intermittent bolus gavage tube feeding of preterm and low birth weight infants
Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Intervention NR
Respiratory rate (breaths per minute) · intermittent bolus gavage tube feeding of preterm and low birth weight infants
Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Intervention NR
Heart rate (beats per minute) at completion of feed · intermittent bolus gavage tube feeding of preterm and low birth weight infants
Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Intervention NR
Heart rate (beats per minute) · intermittent bolus gavage tube feeding of preterm and low birth weight infants
Push versus gravity for intermittent bolus gavage tube feeding of preterm and low birth weight infants (2021) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials)
Full breastfeeding compared with not breastfeeding or partial breastfeeding · preterm infants
Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane
RR 1.47 [1.19, 1.8]6 studies · 1074 participantsLow
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials)
Any breastfeeding (full and partial combined) compared with not breastfeeding · preterm infants
Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane
RR 1.11 [1.06, 1.16]6 studies · 1138 participantsModerate
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials)
Length of hospital stay (days) · preterm infants
Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane
no estimate extracted4 studies · 1004 participantsLow
Breastfeeding with supplemental feeds by other than bottle vs breastfeeding with supplemental feeds by bottle (all trials)
Episodes of infection per infant · preterm infants
Avoidance of bottles during the establishment of breastfeeds in preterm infants (2021) · Cochrane
RR 0.7 [0.35, 1.42]3 studies · 500 participantsLow
Intervention NR
Mortality by hospital discharge · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
RR 1 [0.17, 5.77]2 studies · 44 participantsLow
Intervention NR
Incidence of bronchopulmonary dysplasia · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
RR 0.25 [0.03, 2.07]2 studies · 44 participantsLow
Intervention NR
Duration of supplemental oxygen (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
no estimate extracted2 studies · 44 participantsVery low
Intervention NR
Duration of ventilatory support (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
no estimate extracted2 studies · 44 participantsVery low
Intervention NR
Duration of continuous positive airway pressure therapy (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Duration of neonatal intensive care unit stay (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Duration of hospital stay (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory…
Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated… (2021) · Cochrane
no estimate extractedNRNo studies
Restricted vs standard fluid management
Duration of supplemental oxygen therapy (hours) · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted2 studies · 172 participantsVery low
Restricted vs standard fluid management
Incidence of hypernatremia (serum sodium > 145 mEq/L) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
RR 4 [0.46, 34.54]1 study · 100 participantsVery low
Restricted vs standard fluid management
Incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
RR 1 [0.15, 6.82]2 studies · 164 participantsVery low
Restricted vs standard fluid management
Incidence of endotracheal ventilation (proportions) during hospital stay (for infants on no support or noninvasive support at the time of study entry) · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
RR 0.73 [0.24, 2.23]3 studies · 242 participantsVery low
Restricted vs standard fluid management
Incidence of noninvasive (nasal CPAP or nasal ventilation) respiratory support during hospital stay · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
RR 0.4 [0.14, 1.17]2 studies · 150 participantsVery low
Restricted vs standard fluid management
Length of hospital stay (in days) · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted1 study · 80 participantsVery low
Restricted vs standard fluid management
Cumulative weight loss at 72 hours of age (%) · late preterm and full‐term infants with transient tachypnea of the newborn
Fluid restriction in the management of transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted2 studies · 156 participantsVery low
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
RR 0.59 [0.48, 0.73]10 studies · 1324 participantsModerate
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Need for intubation within the first 72 hours · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
RR 0.63 [0.54, 0.74]12 studies · 1422 participantsModerate
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Air leak requiring drainage · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
RR 0.58 [0.33, 1.02]6 studies · 1036 participantsLow
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Severe intraventricular haemorrhage (grade III or IV) · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
RR 0.63 [0.42, 0.96]5 studies · 857 participantsLow
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Death during first hospitalisation (all causes) · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
RR 0.63 [0.47, 0.84]11 studies · 1424 participantsLow
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Bronchopulmonary dysplasia (BPD) among survivors at 36 weeks' postmenstrual age · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
RR 0.57 [0.45, 0.74]11 studies · 1567 participantsModerate
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)
Death or survival with neurosensory disability ‐ not reported · preterm infants with or at risk of respiratory distress syndrome
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (2021) · Cochrane
no estimate extractedNRNo studies
Salbutamol vs placebo/no treatment
Duration of oxygen therapy (hours) · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted4 studies · 338 participantsVery low
Salbutamol vs placebo/no treatment
Need for continuous positive airway pressure (yes/no) · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
RR 0.73 [0.38, 1.39]1 study · 46 participantsVery low
Salbutamol vs placebo/no treatment
Need for mechanical ventilation (yes/no) · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
RR 0.6 [0.13, 2.86]3 studies · 254 participantsVery low
Salbutamol vs placebo/no treatment
Duration of respiratory support (intermittent positive pressure ventilation or continuous positive airway pressure; hours). · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted2 studies · 228 participantsVery low
Salbutamol vs placebo/no treatment
Duration of hospital stay (days) · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted4 studies · 338 participantsLow
Salbutamol vs placebo/no treatment
Duration of mechanical ventilation (hours) · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
no estimate extractedNRNo studies
Salbutamol vs placebo/no treatment
Pneumothorax (yes/no) · patients with transient tachypnea of the newborn
Salbutamol for transient tachypnea of the newborn (2021) · Cochrane
no estimate extracted1 study · 80 participantsVery low
Short feeding interval vs long feeding interval
Days taken to achieve full feeding · preterm infants < 1500 g
Short versus long feeding interval for bolus feedings in very preterm infants (2021) · Cochrane
no estimate extracted3 studies · 351 participantsLow
Short feeding interval vs long feeding interval
Days to regain birth weight · preterm infants < 1500 g
Short versus long feeding interval for bolus feedings in very preterm infants (2021) · Cochrane
no estimate extracted3 studies · 350 participantsLow
Short feeding interval vs long feeding interval
Duration of hospital stay (days) · preterm infants < 1500 g
Short versus long feeding interval for bolus feedings in very preterm infants (2021) · Cochrane
no estimate extracted2 studies · 207 participantsVery low