Cochrane · systematic review · CD011672
Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome
Abdel-Latif, ME, Davis, PG, Wheeler, KI, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) in preterm infants with or at risk of respiratory distress syndrome
Population: preterm infants with or at risk of respiratory distress syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | RR 0.59 [0.48, 0.73] | 10 studies · 1324 participants | Moderate Downgraded: risk of bias |
Need for intubation within the first 72 hours Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | RR 0.63 [0.54, 0.74] | 12 studies · 1422 participants | Moderate Downgraded: risk of bias |
Air leak requiring drainage Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | RR 0.58 [0.33, 1.02] | 6 studies · 1036 participants | Low Downgraded: risk of bias |
Severe intraventricular haemorrhage (grade III or IV) Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | RR 0.63 [0.42, 0.96] | 5 studies · 857 participants | Low Downgraded: risk of bias |
Death during first hospitalisation (all causes) Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | RR 0.63 [0.47, 0.84] | 11 studies · 1424 participants | Low Downgraded: risk of bias |
Bronchopulmonary dysplasia (BPD) among survivors at 36 weeks' postmenstrual age Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | RR 0.57 [0.45, 0.74] | 11 studies · 1567 participants | Moderate Downgraded: risk of bias |
Death or survival with neurosensory disability ‐ not reported Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT) | no estimate extracted | NR | No studies |