Cochrane · systematic review · CD011466
Fluid restriction in the management of transient tachypnea of the newborn
Gupta, N, Bruschettini, M, Chawla, D · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Restricted compared to standard fluid management in the management of transient tachypnea of the newborn
Population: late preterm and full‐term infants with transient tachypnea of the newborn
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of supplemental oxygen therapy (hours) Restricted vs standard fluid management | no estimate extracted | 2 studies · 172 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of hypernatremia (serum sodium > 145 mEq/L) at end of intervention period (proportions) Restricted vs standard fluid management | RR 4 [0.46, 34.54] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of intervention period (proportions) Restricted vs standard fluid management | RR 1 [0.15, 6.82] | 2 studies · 164 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of endotracheal ventilation (proportions) during hospital stay (for infants on no support or noninvasive support at the time of study entry) Restricted vs standard fluid management | RR 0.73 [0.24, 2.23] | 3 studies · 242 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of noninvasive (nasal CPAP or nasal ventilation) respiratory support during hospital stay Restricted vs standard fluid management | RR 0.4 [0.14, 1.17] | 2 studies · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Length of hospital stay (in days) Restricted vs standard fluid management | no estimate extracted | 1 study · 80 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cumulative weight loss at 72 hours of age (%) Restricted vs standard fluid management | no estimate extracted | 2 studies · 156 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |