Cochrane · systematic review · CD002777
High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm infants
Perretta, L, Ouldibbat, L, Hagadorn, JI, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
7
No studies
2
Included studies
NR
No studies 2 · 22.2%Ungraded 0 · 0%Very low 5 · 55.6%Low 2 · 22.2%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
High MCT formula compared to low MCT formula for promoting short‐term growth of preterm infants ‐ growth outcomes
Population: promoting short‐term growth of preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain, g/kg/d (high MCT vs low MCT) High MCT formula vs low MCT formula | no estimate extracted | 6 studies · 118 participants | Low Downgraded: risk of bias |
Weight gain, g/d (high MCT vs low MCT) High MCT formula vs low MCT formula | no estimate extracted | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Length gain, cm/week (high MCT vs low MCT) High MCT formula vs low MCT formula | no estimate extracted | 3 studies · 61 participants | Very low Downgraded: risk of bias |
Head circumference gain, cm/week (high MCT vs low MCT) High MCT formula vs low MCT formula | no estimate extracted | 3 studies · 61 participants | Low Downgraded: risk of bias |
Skinfold thickness gain (mm/week) (high MCT vs low MCT) High MCT formula vs low MCT formula | no estimate extracted | 2 studies · 32 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
High MCT formula compared to low MCT formula for promoting short‐term growth of preterm infants ‐ adverse or secondary outcomes
Population: promoting short‐term growth of preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gastrointestinal intolerance High MCT formula vs low MCT formula | no estimate extracted | 5 studies · 145 participants | Very low Downgraded: inconsistency |
NEC High MCT formula vs low MCT formula | no estimate extracted | 2 studies · 82 participants | Very low Downgraded: inconsistency |
Neurodevelopmental outcomes High MCT formula vs low MCT formula | no estimate extracted | NR | No studies |
Long‐term growth outcomes High MCT formula vs low MCT formula | no estimate extracted | NR | No studies |