Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

699 questions · 745 findings · 185 reviews

No studies found 180 · 24.2%GRADE not reported 76 · 10.2%Very low 194 · 26%Low 154 · 20.7%Moderate 110 · 14.8%High 31 · 4.2%

Reduced dose of antipsychotics vs antipsychotic maintenance

Leaving the study early · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes acceptability of the treatment: leaving the study early compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Donepezil 23 mg/day vs donepezil 10 mg/day

Secondary outcome: acceptability of treatment · people with Alzheimer's disease

Donepezil 23 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with donepezil 10 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Secondary outcome: acceptability of treatment · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Secondary outcome: acceptability of treatment · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Acceptability · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Acceptability of treatment (17 weeks) · women with a history of postnatal depression
1 finding from 1 review

Intervention not reported

Acceptability of treatment (17 weeks) · women with a history of postnatal depression
1 finding from 1 review

Electromechanical and robotic assisted training vs other interventions

acceptability and safety of treadmill training ‐ No intervention control group (co‐interventions were not similar in both groups) Number of adverse events and drop‐outs · people with stroke
1 finding from 1 review

Client feedback vs no client feedback

Treatment acceptability: dropouts from treatment · children and adolescents, 11 to 18 years old, with mental health problems

It is very uncertain whether client feedback changes treatment acceptability: dropouts from treatment compared with no client feedback (very low certainty).

1 finding from 1 review

Antipsychotic dose increase vs antipsychotic dose continuation

Acceptability of treatment ‐ leaving the study early · non response in schizophrenia

Antipsychotic dose increase showed no clear difference in leaving the study early: acceptability ‐ leaving early due to any… compared with antipsychotic dose continuation (low certainty).

1 finding from 1 review

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + AMISULPIRIDE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + QUETIAPINE (Genc 2007) (very low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010) (very low certainty).

1 finding from 1 review

CLOZAPINE + ZIPRASIDONE vs CLOZAPINE + QUETIAPINE (Wen 2015)

Leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ZIPRASIDONE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + QUETIAPINE (Wen 2015) (very low certainty).

1 finding from 1 review

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ARIPIPRAZOLE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + HALOPERIDOL (Cipriani 2013) (very low certainty).

1 finding from 1 review