Cochrane · systematic review · CD011884
Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia
Samara, MT, Klupp, E, Helfer, B, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 5 · 71.4%Very low 2 · 28.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Increasing the antipsychotic dose compared to switching the antipsychotic drug for non response in schizophrenia
Population: patients with non response in schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: Clinically relevant response – as defined by trial Risk ratio Increasing the antipsychotic dose vs switching the antipsychotic drug | RR 1.63 [0.17, 15.99] | 1 study · 29 participants | Very low Downgraded: imprecision, publication bias |
Leaving the study early: Tolerability ‒leaving the study early due to side effects Increasing the antipsychotic dose vs switching the antipsychotic drug | no estimate extracted | 0 studies · 0 participants | Ungraded |
Leaving the study early: Acceptability ‒leaving the study early due to any reason Increasing the antipsychotic dose vs switching the antipsychotic drug | no estimate extracted | 0 studies · 0 participants | Ungraded |
General mental state ‒BPRS total score at endpoint* Weighted mean difference Increasing the antipsychotic dose vs switching the antipsychotic drug | no estimate extracted | 1 study · 29 participants | Very low Downgraded: imprecision, publication bias |
Adverse effects ‒at least one adverse effect Increasing the antipsychotic dose vs switching the antipsychotic drug | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service use ‒time in hospital Increasing the antipsychotic dose vs switching the antipsychotic drug | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life ‒average change in quality of life Increasing the antipsychotic dose vs switching the antipsychotic drug | no estimate extracted | 0 studies · 0 participants | Ungraded |