Cochrane · systematic review · CD004655
Oral vitamin B₁₂ versus intramuscular vitamin B₁₂ for vitamin B₁₂ deficiency
Wang, H, Li, L, Qin, LL, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
3
No studies
3
Included studies
NR
No studies 3 · 50%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral versus intramuscular vitamin B12 for vitamin B12 deficiency
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum vitamin B12 levels Normal value: > 300 pg/mL (> 221 pmol/L) Oral vs intramuscular vitamin B12 | no estimate extracted | 3 studies · 153 participants | Low Downgraded: imprecision |
Clinical signs and symptoms Oral vs intramuscular vitamin B12 | no estimate extracted | NR | No studies |
Adverse events Oral vs intramuscular vitamin B12 | no estimate extracted | 2 studies · 120 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Oral vs intramuscular vitamin B12 | no estimate extracted | NR | No studies |
Acceptability Oral vs intramuscular vitamin B12 | no estimate extracted | NR | No studies |
Socioeconomic effects Oral vs intramuscular vitamin B12 | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision |