Cochrane · systematic review · CD004363
Antidepressants for preventing postnatal depression
Molyneaux, E, Telesia, LA, Henshaw, C, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
6
Included studies
NR
No studies 6 · 50%Ungraded 0 · 0%Very low 6 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nortripyline for the prevention of postnatal depression
Population: women with a history of postnatal depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postnatal depression (17 weeks) | RR 0.96 [0.36, 2.59] | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects experienced by mother and/or foetus or nursing baby | no estimate extracted | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision |
Acceptability of treatment (17 weeks) | no estimate extracted | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision |
Overall maternal satisfaction (17 weeks) | no estimate extracted | NR | No studies |
Improvement in the maternal relationship with the baby (17 weeks) | no estimate extracted | NR | No studies |
Establishment or continuation of breastfeeding (17 weeks) | no estimate extracted | NR | No studies |
Sertraline for the prevention of postnatal depression
Population: women with a history of postnatal depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postnatal depression (17 weeks) | RR 0.14 [0.02, 1.07] | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects experienced by mother and/or fetus or nursing baby | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision |
Acceptability of treatment (17 weeks) | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision |
Overall maternal satisfaction (17 weeks) | no estimate extracted | NR | No studies |
Improvement in the maternal relationship with the baby (17 weeks) | no estimate extracted | NR | No studies |
Establishment or continuation of breastfeeding (17 weeks) | no estimate extracted | NR | No studies |