Cochrane · systematic review · CD011883
Increasing antipsychotic dose for non response in schizophrenia
Samara, MT, Klupp, E, Helfer, B, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 3 · 42.9%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antipsychotic dose increase compared to antipsychotic dose continuation for non response in schizophrenia
Population: non response in schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: clinically relevant response: Antipsychotic dose increase vs antipsychotic dose continuation | RR 1.09 [0.86, 1.4] | 9 studies · 533 participants | Low Downgraded: imprecision |
Leaving the study early: tolerability ‐ leaving early due to adverse effects. Antipsychotic dose increase vs antipsychotic dose continuation | RR 1.63 [0.52, 5.07] | 7 studies · 496 participants | Very low Downgraded: imprecision |
Leaving the study early: acceptability ‐ leaving early due to any reason. Antipsychotic dose increase vs antipsychotic dose continuation | RR 1.3 [0.89, 1.9] | 5 studies · 353 participants | Low Downgraded: imprecision |
General mental state : PANSS total score change* Antipsychotic dose increase vs antipsychotic dose continuation | no estimate extracted | 3 studies · 258 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Adverse effects ‐ at least one adverse effect Antipsychotic dose increase vs antipsychotic dose continuation | RR 0.91 [0.55, 1.5] | 2 studies · 191 participants | Very low Downgraded: imprecision |
Service use: time in hospital Antipsychotic dose increase vs antipsychotic dose continuation | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life ‐ clinically important change in quality of life (defined as at least 50% improvement in HQLS) Antipsychotic dose increase vs antipsychotic dose continuation | no estimate extracted | 1 study · 17 participants | Low Downgraded: imprecision |