Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,970 questions · 2,433 findings · 231 reviews

No studies found 303 · 12.5%GRADE not reported 759 · 31.2%Very low 357 · 14.7%Low 476 · 19.6%Moderate 418 · 17.2%High 120 · 4.9%

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review

Early enteral nutrition vs delayed enteral nutrition

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

It is very uncertain whether early enteral nutrition changes feed intolerance or gastrointestinal complications (as defined by… compared with delayed enteral nutrition (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

Thromboelastography threshold may leads to lower number of individuals requiring a transfusion within 7 days № of… compared with standard of care (laboratory parameters) (low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes number of individuals requiring a transfusion within 7 days № of… compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

Postoperative residual refractive astigmatism of less than 0.50 D · people with astigmatism who are having cataract surgery (phacoemulsification)

Toric intraocular lens (IOL) probably leads to higher postoperative residual refractive astigmatism of less than 0.50 D compared with limbal relaxing incisions (LRIs) (moderate certainty).

1 finding from 1 review