Cochrane · systematic review · CD007263

Dilute versus full‐strength formula in exclusively formula‐fed preterm or low birth weight infants

Basuki, F, Hadiati, DR, Turner, T, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 3 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Half‐strength formula compared to full‐strength formula for exclusively formula‐fed preterm or low birth weight infants

Population: exclusively formula‐fed preterm or low birth weight infants

6 questions

Outcome	Effect	Evidence	Status / GRADE
Episodes of abdominal distention > 2 cm Half‐strength formula vs full‐strength formula	no estimate extracted	2 studies · 88 participants	Low Downgraded: risk of bias, imprecision
Episodes of gastric residuals3> 50% of last feed remaining Half‐strength formula vs full‐strength formula	no estimate extracted	2 studies · 88 participants	Low Downgraded: risk of bias, imprecision
Days until 420 joules per kilogram Half‐strength formula vs full‐strength formula	no estimate extracted	2 studies · 88 participants	Low Downgraded: risk of bias, imprecision
Necrotising enterocolitis Half‐strength formula vs full‐strength formula	no estimate extracted	NR	No studies
All‐cause mortality prior to hospital discharge Half‐strength formula vs full‐strength formula	no estimate extracted	NR	No studies
Incidence of invasive infection Half‐strength formula vs full‐strength formula	no estimate extracted	NR	No studies