Cochrane · systematic review · CD011980
Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia
Estcourt, LJ, Malouf, R, Hopewell, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
2
No studies
3
Included studies
NR
No studies 3 · 60%Ungraded 0 · 0%Very low 2 · 40%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Platelet transfusion compared with no platelet transfusion for lumbar puncture procedures
Population: People with thrombocytopenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Major procedure‐related bleeding within 24 hours of the procedure Platelet transfusion vs no platelet transfusion | no estimate extracted | 2 studies · 150 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality up to 30 days after the procedure Platelet transfusion vs no platelet transfusion | no estimate extracted | NR | No studies |
Transfusion‐related complications within 24 hours of the procedure Platelet transfusion vs no platelet transfusion | no estimate extracted | NR | No studies |
Procedure‐related (lumbar puncture or epidural anaesthetic) complications within 7 days of the procedure Platelet transfusion vs no platelet transfusion | no estimate extracted | 1 study · 21 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life (as defined by the individual studies) Platelet transfusion vs no platelet transfusion | no estimate extracted | NR | No studies |