Caries increment in permanent teeth · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…
It is very uncertain whether chlorhexidine varnish (10% and 40%) changes caries increment in permanent dentition (DMFS; higher values… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Elevated mutans streptococci levels (>=4 with caries screen; high vs low) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…
It is very uncertain whether chlorhexidine varnish (10%) changes elevated mutans streptococci levels (>=4 with caries screen; high vs… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Death: high‐income countries · patients treated for acute bacterial meningitis
1 finding from 1 review
Deafness: high‐income countries · patients treated for acute bacterial meningitis
1 finding from 1 review
ICU mortality · patients with sepsis
Should high‐volume haemofiltration showed no clear difference in ICU mortality compared with standard or usual dialysis be used (low certainty).
1 finding from 1 review
28‐Day mortality · patients with sepsis
Should high‐volume haemofiltration showed no clear difference in 28‐Day mortality compared with standard or usual dialysis be used (low certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty).
3 findings from 1 review
RR 1.09 [0.93, 1.29]
5 studies · 1655 participants
Moderate
RR 1.19 [1, 1.41]
3 studies · 3446 participants
Moderate
RR 1.48 [1.06, 2.08]
1 study · 537 participants
Moderate
SAEs · people who smoke
Higher‐dose showed no clear difference in overall SAEs ‐ 42/44 mg versus 21/22 mg (24 hr patches) compared with lower‐dose nicotine patch (low certainty).
2 findings from 1 review
Treatment withdrawal · people who smoke
Higher‐dose may leads to higher treatment withdrawals ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).
1 finding from 1 review
Treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) · people who smoke
Higher‐dose showed no clear difference in treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).
1 finding from 1 review
Deaths · patients with acute organophosphate pesticide poisoning
It is very uncertain whether higher dose changes deaths compared with lower dose (very low certainty).
1 finding from 1 review
Intermediate syndrome · patients with acute organophosphate pesticide poisoning
It is very uncertain whether higher dose changes intermediate syndrome compared with lower dose (very low certainty).
1 finding from 1 review
Ventilated · patients with acute organophosphate pesticide poisoning
It is very uncertain whether higher dose changes ventilated compared with lower dose (very low certainty).
1 finding from 1 review
RIFLE (Risk or worse) · patients with Intravascular Volume Depletion
High MW HES showed no clear difference in RIFLE (Risk or worse) compared with low MW HES (moderate certainty).
1 finding from 1 review
RIFLE (Injury or worse) · patients with Intravascular Volume Depletion
High MW HES showed no clear difference in RIFLE (Injury or worse) compared with low MW HES (moderate certainty).
1 finding from 1 review
RIFLE (Failure) · patients with Intravascular Volume Depletion
1 finding from 1 review
Overall mortality · preterm infants with severe pulmonary dysfunction
Rescue high‐frequency jet ventilation showed no clear difference in overall mortality compared with conventional ventilation (low certainty).
1 finding from 1 review
Mortality before cross‐over · preterm infants with severe pulmonary dysfunction
Rescue high‐frequency jet ventilation probably leads to lower mortality before cross‐over compared with conventional ventilation (moderate certainty).
1 finding from 1 review
Chronic lung disease · preterm infants with severe pulmonary dysfunction
Rescue high‐frequency jet ventilation showed no clear difference in chronic lung disease at 28 days of birth (CLD 28 days) compared with conventional ventilation (low certainty).
2 findings from 1 review
Pulmonary air leak (new) · preterm infants with severe pulmonary dysfunction
Rescue high‐frequency jet ventilation showed no clear difference in pulmonary air leak (new) compared with conventional ventilation (low certainty).
1 finding from 1 review