Cochrane · systematic review · CD001832
Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis
Prasad, K, Kumar, A, Singhal, T, et al. · Cochrane Database of Systematic Reviews · 2007 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
0
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 16 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Third generation cephalosporins versus conventional therapy for acute bacterial meningitis
Population: patients treated for acute bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Third generation cephalosporins vs conventional therapy | no estimate extracted | 19 studies · 1496 participants | Ungraded |
Deafness Third generation cephalosporins vs conventional therapy | no estimate extracted | 10 studies · 501 participants | Ungraded |
Culture positivity 10 to 48 hours start of treatment Third generation cephalosporins vs conventional therapy | no estimate extracted | 12 studies · 442 participants | Ungraded |
Diarrhoea Third generation cephalosporins vs conventional therapy | no estimate extracted | 12 studies · 750 participants | Ungraded |
Neutropenia Third generation cephalosporins vs conventional therapy | no estimate extracted | 10 studies · 472 participants | Ungraded |
Skin rash Third generation cephalosporins vs conventional therapy | no estimate extracted | 8 studies · 533 participants | Ungraded |
Treatment failure (either death or deafness) Third generation cephalosporins vs conventional therapy | no estimate extracted | 19 studies · 1496 participants | Ungraded |
Cephalosporins versus conventional therapy for H. influenzae meningitis
Population: patients treated for H. influenzae meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Cephalosporins vs conventional therapy | no estimate extracted | 10 studies · 318 participants | Ungraded |
Third generation cephalosporins versus conventional antibiotics for S. pneumoniae meningitis
Population: patients treated for S. pneumoniae meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Third generation cephalosporins vs conventional antibiotics | no estimate extracted | 11 studies · 129 participants | Ungraded |
Third generation cephalosporins versus conventional therapy for meningococcal meningitis
Population: patients treated for meningococcal meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Third generation cephalosporins vs conventional therapy | no estimate extracted | 13 studies · 477 participants | Ungraded |
Third generation cephalosporins versus conventional antibiotics (high and low/middle‐income countries) for acute bacterial meningitis
Population: patients treated for acute bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries) | no estimate extracted | 19 studies · 1301 participants | Ungraded |
Death: high‐income countries Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries) | no estimate extracted | 9 studies · 510 participants | Ungraded |
Death: Low/middle‐income countries Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries) | no estimate extracted | 10 studies · 791 participants | Ungraded |
Deafness Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries) | no estimate extracted | 10 studies · 501 participants | Ungraded |
Deafness: high‐income countries Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries) | no estimate extracted | 6 studies · 380 participants | Ungraded |
Deafness: low‐income countries Third generation cephalosporins vs conventional antibiotics (high and low/middle‐income countries) | no estimate extracted | 4 studies · 121 participants | Ungraded |