Cochrane · systematic review · CD007594
Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function
Dart Allison B, Mutter Thomas C, Ruth Chelsea A, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 7.7%Moderate 8 · 61.5%High 4 · 30.8%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
HES versus other fluids for intravascular volume depletion
Population: patients with Intravascular Volume Depletion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Renal Replacement Therapy ‐ Sepsis HES vs other fluids | RR 1.59 [1.2, 2.1] | 3 studies · 702 participants | High |
Renal Replacement Therapy ‐ Non‐Sepsis HES vs other fluids | RR 0.44 [0.14, 1.38] | 8 studies · 487 participants | Moderate |
Renal Failure (author defined) ‐ Sepsis HES vs other fluids | RR 1.55 [1.22, 1.96] | 4 studies · 832 participants | Moderate |
Renal Failure (author defined) ‐ Non‐Sepsis HES vs other fluids | RR 1.13 [0.57, 2.25] | 5 studies · 367 participants | Low |
HES versus other fluids for intravascular volume depletion
Population: patients with Intravascular Volume Depletion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
RIFLE (Risk or worse) ‐ Sepsis HES vs other fluids | RR 1.28 [0.81, 2.02] | 2 studies · 140 participants | High |
RIFLE (Risk or worse) ‐ Non‐Sepsis HES vs other fluids | RR 0.88 [0.27, 2.85] | 2 studies · 185 participants | Moderate |
RIFLE (Injury or worse) ‐ Sepsis HES vs other fluids | RR 1.39 [0.84, 2.3] | 2 studies · 140 participants | High |
RIFLE (Injury or worse) ‐ Non‐Sepsis HES vs other fluids | RR 0.81 [0.12, 5.4] | 2 studies · 185 participants | Moderate |
RIFLE (Failure) ‐ Sepsis HES vs other fluids | RR 1.45 [0.8, 2.64] | 2 studies · 140 participants | High |
RIFLE (Failure) ‐ Non‐Sepsis HES vs other fluids | RR 0.49 [0.07, 3.73] | 2 studies · 185 participants | Moderate |
High MW HES versus Low MW HES for intravascular volume depletion
Population: patients with Intravascular Volume Depletion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
RIFLE (Risk or worse) High MW HES vs Low MW HES | RR 0.54 [0.05, 5.59] | 2 studies · 113 participants | Moderate |
RIFLE (Injury or worse) High MW HES vs Low MW HES | RR 3.21 [0.14, 75.68] | 3 studies · 162 participants | Moderate |
RIFLE (Failure) High MW HES vs Low MW HES | no estimate extracted | 3 studies · 162 participants | Moderate |