Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,841 questions · 1,893 findings · 109 reviews · Headline outcomes only

No studies found 546 · 28.8%GRADE not reported 117 · 6.2%Very low 613 · 32.4%Low 473 · 25%Moderate 118 · 6.2%High 26 · 1.4%

Intervention not reported

Non‐nicotine/placebo EC · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in non‐nicotine/placebo EC (low certainty).

1 finding from 1 review

Intervention not reported

Nortriptyline · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention probably leads to higher nortriptyline (moderate certainty).

1 finding from 1 review

Prism adaptation training vs control

Activities of daily living · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

It is very uncertain whether prism adaptation training changes activities of daily living: immediate effects compared with any control (very low certainty).

2 findings from 1 review

Prism adaptation training vs control

Neglect outcomes: effects persisting at least 1 month post intervention · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

It is very uncertain whether prism adaptation training changes neglect outcomes: effects persisting at least 1 month post… compared with any control (very low certainty).

1 finding from 1 review

NIBS vs control

Activities of daily living · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

It is very uncertain whether NIBS changes activities of daily living: effects persisting at least 1 month post… compared with any control (very low certainty).

2 findings from 1 review

NIBS vs control

Neglect outcomes: effects persisting at least 1 month post intervention · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

It is very uncertain whether NIBS changes neglect outcomes: effects persisting at least 1 month post… compared with any control (very low certainty).

1 finding from 1 review

Electrical stimulation vs control

Activities of daily living · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

The review found no eligible studies for this question.

2 findings from 1 review

Electrical stimulation vs control

Neglect outcomes: effects persisting at least 1 month post intervention · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture vs control

Activities of daily living · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

The review found no eligible studies for this question.

2 findings from 1 review

Acupuncture vs control

Neglect outcomes: effects persisting at least 1 month post intervention · spatial neglect or inattention following stroke and other adult‐acquired non‐progressive brain injury

The review found no eligible studies for this question.

1 finding from 1 review

New‐generation antidepressants vs placebo

Repetition of SH at post‐intervention · self‐harm in adults

It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class)№ of participants:… compared with placebo (very low certainty).

3 findings from 1 review

Mood stabilisers vs placebo

Repetition of SH at post‐intervention · self‐harm in adults

It is very uncertain whether mood stabilisers, including antiepileptics and lithium changes repetition of SH by post‐intervention№ of participants: 167(1 RCT) compared with placebo (very low certainty).

1 finding from 1 review