New‐generation antidepressants vs placebo: Repetition of SH at post‐intervention
It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class)№ of participants:… compared with placebo (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Newer generation antidepressants (NGAs) vs placebo Repetition of SH by post‐intervention (NGA class)№ of participants: 129(2 RCTs) · Self‐harm in adults It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class)№ of participants:… compared with placebo (very low certainty). Pharmacological interventions for self‐harm in adults (2021) · Cochrane Headline outcomes only | OR 0.59 [0.29, 1.19] | Not reported | Very low |
Newer generation antidepressants (NGAs) vs placebo Repetition of SH by post‐intervention (NGA class) ‐ Mianserin vs. Placebo№ of participants: 38(1 RCT) · Self‐harm in adults It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class) ‐ Mianserin vs.… compared with placebo (very low certainty). Pharmacological interventions for self‐harm in adults (2021) · Cochrane Headline outcomes only | OR 0.67 [0.18, 2.41] | Not reported | Very low |
Newer generation antidepressants (NGAs) vs placebo Repetition of SH by post‐intervention (NGA class) ‐ Paroxetine vs. Placebo№ of participants: 91(1 RCT) · Self‐harm in adults Newer generation antidepressants (NGAs) showed no clear difference in repetition of SH by post‐intervention (NGA class) ‐ Paroxetine vs.… compared with placebo (low certainty). Pharmacological interventions for self‐harm in adults (2021) · Cochrane Headline outcomes only | OR 0.55 [0.24, 1.29] | Not reported | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological interventions for self‐harm in adults 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.