Cochrane · systematic review · CD013669
Pharmacological interventions for self‐harm in adults
Witt, KG, Hetrick, SE, Rajaram, G, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Newer generation antidepressants (NGAs) compared to placebo for self‐harm in adults
Population: Self‐harm in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH by post‐intervention (NGA class)№ of participants: 129(2 RCTs) Newer generation antidepressants (NGAs) vs placebo | OR 0.59 [0.29, 1.19] | NR | Very low Downgraded: risk of bias |
Repetition of SH by post‐intervention (NGA class) ‐ Mianserin vs. Placebo№ of participants: 38(1 RCT) Newer generation antidepressants (NGAs) vs placebo | OR 0.67 [0.18, 2.41] | NR | Very low Downgraded: risk of bias |
Repetition of SH by post‐intervention (NGA class) ‐ Paroxetine vs. Placebo№ of participants: 91(1 RCT) Newer generation antidepressants (NGAs) vs placebo | OR 0.55 [0.24, 1.29] | NR | Low Downgraded: risk of bias |
Antipsychotics compared to placebo for self‐harm in adults
Population: Self‐harm in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH by post‐intervention№ of participants: 30(1 RCT) Antipsychotics vs placebo | OR 0.09 [0.02, 0.5] | NR | Low Downgraded: risk of bias |
Antipsychotics compared to another comparator drug or dose for self‐harm in adults
Population: Self‐harm in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH by post‐intervention№ of participants: 53(1 RCT) Antipsychotics vs another comparator drug or dose | OR 1.51 [0.5, 4.58] | NR | Low |
Mood stabilisers, including antiepileptics and lithium compared to placebo for self‐harm in adults
Population: Self‐harm in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH by post‐intervention№ of participants: 167(1 RCT) Mood stabilisers, including antiepileptics and lithium vs placebo | OR 0.99 [0.33, 2.95] | NR | Very low Downgraded: risk of bias |
Natural products compared to placebo for self‐harm in adults
Population: Self‐harm in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH by post‐intervention№ of participants: 49(1 RCT) Natural products vs placebo | OR 1.33 [0.38, 4.62] | NR | Low |