Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Phacoemulsification vs laser peripheral iridotomy

Proportion of participants with 1 or more recurrent APAC episodes in the same eye (lower number of events is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

It is very uncertain whether phacoemulsification changes proportion of participants with 1 or more recurrent APAC episodes in… compared with laser peripheral iridotomy (very low certainty).

1 finding from 1 review

Intervention not reported

TUG (lower score = faster) · adults following hip fracture surgery

The intervention showed no clear difference in TUG (lower score = faster) (low certainty).

1 finding from 1 review

Intervention not reported

TUG (lower score = faster) · adults following hip fracture surgery

It is very uncertain whether the intervention changes TUG (lower score = faster) (very low certainty).

1 finding from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Adverse events (pain and swelling at injection site and limitation of elbow movement following injection) · lateral elbow pain

Autologous blood or PRP showed no clear difference in adverse events (pain and swelling at injection site and limitation… compared with placebo at 3 months' follow‐up (low certainty).

1 finding from 1 review

High vs low omega‐3 fats

Serum low‐density lipoprotein (LDL, mmol/L) · adults with or without existing CVD
2 findings from 1 review

tDCS vs placebo or control

Secondary outcome measure: lower extremity function at the end of · patients with improving activities of daily living, and physical and cognitive functioning at the end of follow‐up, in people after stroke

The review found no eligible studies for this question.

1 finding from 1 review

Direct oral anticoagulant secondary prophylaxis vs Low molecular weight heparin secondary prophylaxis

Major lower GI bleeding · patients with cancer with venous thromboembolism

It is very uncertain whether direct oral anticoagulant secondary prophylaxis changes major lower GI bleeding compared with low molecular weight heparin secondary prophylaxis (very low certainty).

1 finding from 1 review

Direct oral anticoagulant secondary prophylaxis vs Low molecular weight heparin secondary prophylaxis

Minor lower GI bleeding · patients with cancer with venous thromboembolism

Direct oral anticoagulant secondary prophylaxis showed no clear difference in minor lower GI bleeding compared with low molecular weight heparin secondary prophylaxis (low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Success rate of replantation1 (analysed by participant) · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes success rate of replantation1 (analysed by participant, compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Success rate of replantation1 (analysed by digit, · patients undergoing digital replantation after traumatic amputation

Low molecular weight heparin showed no clear difference in success rate of replantation1 (analysed by digit, compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by participant/digit, · patients undergoing digital replantation after traumatic amputation

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ arterial… compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by participant, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ venous… compared with unfractionated heparin (very low certainty).

1 finding from 1 review