Cochrane · systematic review · CD009894
Low molecular weight heparin for prevention of microvascular occlusion in digital replantation
Lin, PT, Wang, SH, Chi, CC · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
4
Included studies
NR
No studies 4 · 28.6%Ungraded 0 · 0%Very low 8 · 57.1%Low 2 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Low molecular weight heparin versus unfractionated heparin for prevention of microvascular occlusion in digital replantation
Population: patients undergoing digital replantation after traumatic amputation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Success rate of replantation1 (analysed by participant, Low molecular weight heparin vs unfractionated heparin | RR 0.98 [0.87, 1.1] | 2 studies · 130 participants | Very low Downgraded: risk of bias, imprecision |
Success rate of replantation1 (analysed by digit, Low molecular weight heparin vs unfractionated heparin | RR 0.97 [0.9, 1.04] | 2 studies · 200 participants | Low Downgraded: risk of bias, imprecision |
Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by participant/digit, Low molecular weight heparin vs unfractionated heparin | no estimate extracted | NR | No studies |
Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by participant/digit, Low molecular weight heparin vs unfractionated heparin | no estimate extracted | NR | No studies |
Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by participant/digit, Low molecular weight heparin vs unfractionated heparin | RR 1.08 [0.16, 7.1] | 1 study · 54 participants | Very low Downgraded: risk of bias, imprecision |
Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by participant, Low molecular weight heparin vs unfractionated heparin | RR 0.81 [0.2, 3.27] | 1 study · 54 participants | Very low Downgraded: risk of bias, imprecision |
Complication and adverse reactions ‐ wound bleeding (analysed by participant, Low molecular weight heparin vs unfractionated heparin | RR 0.53 [0.23, 1.23] | 2 studies · 130 participants | Low Downgraded: risk of bias, imprecision |
Low molecular weight heparin (LMWH) versus no LMWH for prevention of microvascular occlusion in digital replantation
Population: patients undergoing digital replantation after traumatic amputation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Success rate of replantation1 (analysed by participant) Low molecular weight heparin (LMWH) vs no LMWH | no estimate extracted | NR | No studies |
Success rate of replantation1 (analysed by digit, Low molecular weight heparin (LMWH) vs no LMWH | RR 1.11 [0.93, 1.33] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by digit, Low molecular weight heparin (LMWH) vs no LMWH | RR 0.86 [0.21, 3.58] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by digit, Low molecular weight heparin (LMWH) vs no LMWH | RR 0.72 [0.26, 1.98] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by digit, Low molecular weight heparin (LMWH) vs no LMWH | RR 0.66 [0.21, 2.05] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by digit, Low molecular weight heparin (LMWH) vs no LMWH | RR 0.72 [0.26, 1.98] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Complication and adverse reactions ‐ wound bleeding (analysed by participant, Low molecular weight heparin (LMWH) vs no LMWH | no estimate extracted | NR | No studies |