Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Control showed no significant difference in 24 h bond strength (MD 1.530, 95% CI -2.373 to 5.434; Moderate certainty).
3 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + biological ACAD protocol network, Fluorine showed 4.197 MPa higher 24 h bond strength than Control (MD 4.197, 95% CI 1.080 to 7.314; Moderate certainty).
3 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids showed 8.438 MPa higher 24 h bond strength than Control (MD 8.438, 95% CI 2.289 to 14.587; Moderate certainty).
2 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, HAp vs Control showed no significant difference in 24 h bond strength (MD -2.916, 95% CI -5.854 to 0.023; Moderate certainty).
2 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Control showed no significant difference in 24 h bond strength (MD 0.840, 95% CI -5.270 to 6.950; Low certainty).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Control showed no significant difference in 24 h bond strength (MD 1.539, 95% CI -1.738 to 4.817; Moderate certainty).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium vs Control showed no significant difference in 24 h bond strength (MD -1.124, 95% CI -5.917 to 3.670; Moderate certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Compared with other caries-management methods, SDF may increase caries arrestment at the individual level, but the pooled estimate is very imprecise (low certainty).
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably results in a slight increase in tooth-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably makes little to no difference to surface-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Adverse effects (tooth staining and other side effects) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).
1 finding from 1 review
CA VI activity · Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years), qualitative only…
Salivary/biofilm CA VI activity is significantly higher in individuals with dental caries than in caries-free individuals (SMD 0.894, 95% CI 0.386 to 1.392; not GRADE-rated).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with ceramic restorations was 5.59%.
1 finding from 1 review
Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents)
In permanent dentition, the pooled prevalence of dental caries was 57.2% (95% CI 26.3 to 85.3); ungraded.
10 findings from 1 review
Show 7 more findings
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys) · Province: Sindh
Prevalence 58.946 [43.796, 73.274]
11 studies
GRADE not reported
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys) · Dentition: primary
Prevalence 50.493 [43.867, 57.110]
Studies not reported
GRADE not reported
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys) · City: Karachi
Prevalence 61.988 [45.504, 77.161]
7 studies
GRADE not reported
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys) · Province: Punjab
Prevalence 55.445 [44.174, 66.44]
13 studies
GRADE not reported
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys) · City: Lahore
Prevalence 57.604 [47.727, 67.183]
4 studies
GRADE not reported
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys) · Province: Baluchistan and KPK (combined)
Prevalence 51.168 [22.930, 79.004]
4 studies
GRADE not reported
Prevalence of dental caries in Pakistan: a systematic review and meta-analysis. 2021 All outcomesPakistan (school-, community-, and hospital/clinic-based cross-sectional surveys)
Prevalence 56.625 [49.546, 63.571]
30 studies · 27878 participants
GRADE not reported
DMFT/DMFS index (dental caries experience) · People who use drugs (PWUD): methamphetamine, heroin, opiate, cannabis and cocaine users
Illicit drug use was associated with substantially higher odds of dental caries experience (DMFT) (pooled OR 4.11, 95% CI 2.07-8.15; 7 studies; high heterogeneity I2=90.5%; ungraded).
1 finding from 1 review
Periodontal disease · People who use drugs (PWUD): methamphetamine, heroin, opiate, cannabis and cocaine users
Illicit drug use was not significantly associated with periodontal disease (pooled OR 1.44, 95% CI 0.80-2.60; 5 studies; substantial heterogeneity I2=85%; ungraded).
1 finding from 1 review
Dental caries · Adult participants in 25 meta-regression studies
The unadjusted meta-regression coefficient for low socioeconomic status was 10.49365.
2 findings from 1 review
Marginal adaptation (clinically detectable deterioration) · People with permanent posterior teeth restored with class I or II direct restorations
At 60 months, marginal adaptation did not differ significantly between the composites (4 groups; ungraded).
5 findings from 1 review
Show 2 more findings
Dental caries · Adult participants in 25 meta-regression studies
The Model 1 adjusted meta-regression coefficient for quantitative HDI was -42.94101.
3 findings from 1 review
Meta-regression coefficient -42.94101
6 studies
GRADE not reported
Meta-regression coefficient 20.17878
25 studies
GRADE not reported
Meta-regression coefficient 6.901906
7 studies
GRADE not reported
Secondary caries · People with permanent posterior teeth restored with class I or II direct restorations
No secondary caries was reported at 24 months in any of seven studies, so no meta-analysis was possible (ungraded).
2 findings from 1 review