Question · asked by 1 review
Silver diamine fluoride (SDF) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo): Adverse effects (tooth staining and other side effects)
- Population
- Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
- Intervention
- Silver diamine fluoride (SDF)
- Comparison
- Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo)
- Outcome
- Adverse effects (tooth staining and other side effects)
SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Silver diamine fluoride (SDF; 38% in most trials, 30% in three) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo) Adverse effects (tooth staining; soft-tissue and systemic events) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · up to 30 months, Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded). The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… (2024) All outcomes | Black staining of arrested lesions reported in most studies; 4 studies reported mild transient events (gingival blenching/pain; diarrhea/stomachache; burning, bad taste, pain, mouth injury, dissatisfaction with… | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and meta-analysis. 2024 All outcomes | Not specified (publication window 2014-2024; references accessed July 2024) | 20 | Critically Low / Critically Low |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.