Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Oral vs systemic antibiotic (IM or IV)
Fever · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 1.8 [0.24, 13.45]3 studies · 522 participantsModerate
Oral vs systemic antibiotic (IM or IV)
UTI · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 0.85 [0.27, 2.7]3 studies · 508 participantsModerate
Oral vs systemic antibiotic (IM or IV)
Hospitalization · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 1.8 [0.24, 13.45]2 studies · 407 participantsLow
Antibiotic vs placebo
Bacteremia · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 0.67 [0.49, 0.92]6 studies · 494 participantsModerate
Antibiotic vs placebo
Fever · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 0.39 [0.23, 0.64]9 studies · 820 participantsModerate
Antibiotic vs placebo
UTI · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 0.37 [0.22, 0.62]5 studies · 1077 participantsModerate
Antibiotic vs placebo
Hospitalization · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 0.13 [0.03, 0.55]3 studies · 650 participantsModerate
Antibiotic vs placebo
Adverse event · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 1.62 [0.23, 11.56]2 studies · 127 participantsLow
Short course vs long course treatment
Bacteriuria · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 2.09 [1.17, 3.73]3 studies · 869 participantsModerate
Short course vs long course treatment
Fever · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 2.84 [0.99, 8.16]4 studies · 652 participantsModerate
Short course vs long course treatment
UTI · patients submitted to transrectal prostate biopsy
Antibiotic prophylaxis for transrectal prostate biopsy (2011) · Cochrane
RR 1.4 [0.73, 2.68]5 studies · 1312 participantsModerate
Intervention NR
Poor compliance with study protocol · people with schizophrenia or like psychosis
Aripiprazole versus placebo for schizophrenia (2011) · Cochrane
RR 0.72 [0.53, 0.97]8 studies · 2275 participantsLow
Intervention NR
Relapse · people with schizophrenia or like psychosis
Aripiprazole versus placebo for schizophrenia (2011) · Cochrane
RR 0.66 [0.57, 0.75]2 studies · 573 participantsLow
Intervention NR
Weight gain (equal or greater then 7% of baseline) · people with schizophrenia or like psychosis
Aripiprazole versus placebo for schizophrenia (2011) · Cochrane
RR 2.33 [1.17, 4.66]3 studies · 615 participantsLow
Intervention NR
Concomitant medication (Anxiolytic ‐ Lorazepam) · people with schizophrenia or like psychosis
Aripiprazole versus placebo for schizophrenia (2011) · Cochrane
OR 0.962 studies · 787 participantsLow
Intervention NR
Maternal parasitaemia (at delivery) · HIV‐positive pregnant women living
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.25 [0.14, 0.43]2 studies · 463 participantsLow
Intervention NR
Neonatal mortality · HIV‐positive pregnant women
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
no estimate extractedNRVery low
Intervention NR
Placental parasitaemia (at delivery) · HIV‐positive pregnant women living
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.38 [0.21, 0.7]2 studies · 459 participantsLow
Intervention NR
Maternal anaemia (Hb < 11 g/dL at delivery) · HIV‐positive pregnant women living
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.93 [0.72, 1.2]2 studies · 447 participantsLow
Intervention NR
Low birth weight (< 2.5 kg) · HIV‐positive pregnant women living
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.8 [0.52, 1.23]2 studies · 469 participantsLow
Intervention NR
Neonatal mortality · HIV‐positive pregnant women living
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.29 [0.08, 1.05]1 study · 253 participantsVery low
Intervention NR
Maternal parasitaemia (at delivery) · HIV‐positive pregnant women
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.94 [0.06, 14.75]1 study · 159 participantsVery low
Intervention NR
Placental parasitaemia (at delivery) · HIV‐positive pregnant women
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 1.87 [0.17, 20.23]1 study · 153 participantsVery low
Intervention NR
Maternal anaemia (Hb < 11 g/dL at delivery) · HIV‐positive pregnant women
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 0.98 [0.69, 1.4]1 study · 157 participantsVery low
Intervention NR
Low birth weight (< 2.5 kg) · HIV‐positive pregnant women
Intermittent preventive treatment regimens for malaria in HIV‐positive pregnant women (2011) · Cochrane
RR 1.41 [0.57, 3.51]1 study · 155 participantsVery low
Natural frequencies vs probabilities
Understanding (measured as correct estimate or interpretation of a risk) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted642 participantsModerate
Absolute risk reduction (ARR) vs number needed
Persuasiveness (measured as a hypothetical decision or intention or willingness to adopt an intervention) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted9024 participantsModerate
Relative risk reduction (RRR) vs absolute risk reduction (ARR)
Understanding (measured as correct estimate or interpretation of a risk reduction) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted469 participantsModerate
Relative risk reduction (RRR) vs absolute risk reduction (ARR)
Perception (measured as rating on a scale of perceived effectiveness) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted1116 participantsLow
Relative risk reduction (RRR) vs absolute risk reduction (ARR)
Persuasiveness (measured as a hypothetical decision or intention or willingness to adopt an intervention) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted11221 participantsModerate
Relative risk reduction (RRR) vs number needed
Understanding (measured as correct estimate or interpretation of a risk reduction) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted182 participantsModerate
Relative risk reduction (RRR) vs number needed
Perception (measured as rating on a scale of perceived effectiveness) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted970 participantsModerate
Relative risk reduction (RRR) vs number needed
Persuasiveness (measured as a hypothetical decision or intention or willingness to adopt an intervention) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted9582 participantsModerate
Absolute risk reduction (ARR) vs number needed
Understanding (measured as correct estimate or interpretation of a risk reduction) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted182 participantsModerate
Absolute risk reduction (ARR) vs number needed
Perception (measured as rating on a scale of perceived effectiveness) · health professionals and consumers
Using alternative statistical formats for presenting risks and risk reductions (2011) · Cochrane
no estimate extracted949 participantsModerate
Intervention NR
Understanding · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted1 study · 124 participantsLow
Intervention NR
Behavior · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted16 studies · 11629 participantsLow
Intervention NR
Perception (measured as rating on a scale of perceived effectiveness) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted2 studies · 226 participantsLow
Intervention NR
Persuasiveness (measured as a hypothetical decision or intention or willingness to adopt an intervention) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted8 studies · 1068 participantsLow
Intervention NR
Behavior · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted1 study · 282 participantsModerate
Intervention NR
Perception ‐ screening message (measured as rating on a scale of perceived effectiveness) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted5 studies · 513 participantsModerate
Intervention NR
Perception ‐ prevention message (measured as rating on a scale of perceived effectiveness) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted9 studies · 815 participantsLow
Intervention NR
Persuasiveness ‐ screening message (measured as a hypothetical decision or intention or willingness to adopt an intervention) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted6 studies · 931 participantsLow
Intervention NR
Persuasiveness ‐ prevention message (measured as a hypothetical decision or intention or willingness to adopt an intervention) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted13 studies · 1496 participantsLow
Intervention NR
Persuasiveness ‐ treatment message (measured as a hypothetical decision or intention or willingness to adopt an intervention) · consumers
Framing of health information messages (2011) · Cochrane
no estimate extracted3 studies · 1788 participantsVery low
Intervention NR
Quality of life (3 to 8 months) · patients with treatment of inflammatory bowel disease
Psychological interventions for treatment of inflammatory bowel disease (2011) · Cochrane
no estimate extracted3 studies · 173 participantsVery low
Intervention NR
Depression and anxiety at 3 to 8 months ‐ Anxiety · patients with treatment of inflammatory bowel disease
Psychological interventions for treatment of inflammatory bowel disease (2011) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Intervention NR
Quality of life (3 to 8 months) · patients with treatment of inflammatory bowel disease
Psychological interventions for treatment of inflammatory bowel disease (2011) · Cochrane
no estimate extracted7 studies · 596 participantsVery low
Intervention NR
Quality of life (9 to 18 months) · patients with treatment of inflammatory bowel disease
Psychological interventions for treatment of inflammatory bowel disease (2011) · Cochrane
no estimate extracted5 studies · 947 participantsVery low
Intervention NR
Depression (3 to 8 months) · patients with treatment of inflammatory bowel disease
Psychological interventions for treatment of inflammatory bowel disease (2011) · Cochrane
no estimate extracted4 studies · 430 participantsVery low