Cochrane · systematic review · CD006576
Antibiotic prophylaxis for transrectal prostate biopsy
Zani, EL, Clark, OAC, Rodrigues Netto Jr, N · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
18
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 27.8%Moderate 13 · 72.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotic compared to placebo for patients submitted to transrectal prostate biopsy
Population: patients submitted to transrectal prostate biopsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bacteriuria Antibiotic vs placebo | RR 0.25 [0.15, 0.42] | 8 studies · 870 participants | Moderate Downgraded: risk of bias |
Bacteremia Antibiotic vs placebo | RR 0.67 [0.49, 0.92] | 6 studies · 494 participants | Moderate Downgraded: risk of bias |
Fever Antibiotic vs placebo | RR 0.39 [0.23, 0.64] | 9 studies · 820 participants | Moderate Downgraded: risk of bias |
UTI Antibiotic vs placebo | RR 0.37 [0.22, 0.62] | 5 studies · 1077 participants | Moderate Downgraded: risk of bias |
Hospitalization Antibiotic vs placebo | RR 0.13 [0.03, 0.55] | 3 studies · 650 participants | Moderate Downgraded: risk of bias |
Adverse event Antibiotic vs placebo | RR 1.62 [0.23, 11.56] | 2 studies · 127 participants | Low Downgraded: risk of bias, imprecision |
Short course compared to long course treatment for patients submitted to transrectal prostate biopsy
Population: patients submitted to transrectal prostate biopsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bacteriuria Short course vs long course treatment | RR 2.09 [1.17, 3.73] | 3 studies · 869 participants | Moderate Downgraded: risk of bias |
Fever Short course vs long course treatment | RR 2.84 [0.99, 8.16] | 4 studies · 652 participants | Moderate Downgraded: risk of bias |
UTI Short course vs long course treatment | RR 1.4 [0.73, 2.68] | 5 studies · 1312 participants | Moderate Downgraded: risk of bias |
Hospitalization Short course vs long course treatment | RR 4.14 [0.47, 36.46] | 2 studies · 366 participants | Low Downgraded: risk of bias, imprecision |
Single dose compared to multiple dose antibiotic for patients submitted to transrectal prostate biopsy
Population: patients submitted to transrectal prostate biopsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bacteriuria Single dose vs multiple dose antibiotic | RR 1.98 [1.18, 3.33] | 4 studies · 944 participants | Moderate Downgraded: risk of bias |
Fever Single dose vs multiple dose antibiotic | RR 2.84 [0.99, 8.16] | 4 studies · 652 participants | Low Downgraded: risk of bias |
UTI Single dose vs multiple dose antibiotic | RR 1.4 [0.73, 2.68] | 5 studies · 1312 participants | Moderate Downgraded: risk of bias |
Hospitalization Single dose vs multiple dose antibiotic | RR 3.1 [0.64, 15.06] | 3 studies · 441 participants | Low Downgraded: risk of bias |
Oral compared to systemic antibiotic (IM or IV) for patients submitted to transrectal prostate biopsy
Population: patients submitted to transrectal prostate biopsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bacteriuria Oral vs systemic antibiotic (IM or IV) | RR 0.34 [0.06, 1.93] | 3 studies · 354 participants | Moderate Downgraded: inconsistency |
Fever Oral vs systemic antibiotic (IM or IV) | RR 1.8 [0.24, 13.45] | 3 studies · 522 participants | Moderate Downgraded: risk of bias |
UTI Oral vs systemic antibiotic (IM or IV) | RR 0.85 [0.27, 2.7] | 3 studies · 508 participants | Moderate Downgraded: risk of bias |
Hospitalization Oral vs systemic antibiotic (IM or IV) | RR 1.8 [0.24, 13.45] | 2 studies · 407 participants | Low Downgraded: risk of bias, imprecision |