Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

489 questions · 504 findings · 104 reviews

No studies found 32 · 6.3%GRADE not reported 63 · 12.5%Very low 152 · 30.2%Low 133 · 26.4%Moderate 103 · 20.4%High 21 · 4.2%

rHuEPO with iron vs control treatment with or without iron

Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO low (150 to 300 IU/kg BW) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

Intervention not reported

Complete resolution of symptoms (proportion of patients with 'immediate and persistent resolution of symptoms' from the point of surgery/randomisation up to end of study · children with PFAPA

The intervention showed no clear difference in complete resolution of symptoms (proportion of patients with… (moderate certainty).

1 finding from 1 review

Herbal treatment vs placebo

Participant‐reported pain relief of 30% or greater · adults with neuropathic pain

It is very uncertain whether herbal treatment changes participant‐reported pain relief of 30% or greater Immediately… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects Defined as deaths, hospitalisations, congenital abnormalities and life‐threatening conditions requiring an immediate hospital visit Assessed at 12 and 18 months of age · children aged 6 to 23 months

The intervention showed no clear difference in adverse effects Defined as deaths, hospitalisations, congenital… (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine
1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… led to lower number of immediate and delayed postoperative bleeding episodes… compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Postoperative pain during the immediate recovery period (VAS 0 to 10) · Adults (>16 years old) undergoing orthognathic surgery

It is very uncertain whether resorbable (bioresorbable) plates or screws for fixation changes postoperative pain during the immediate recovery period (VAS 0 to 10) compared with titanium plates or screws for fixation (very low certainty).

1 finding from 1 review

Intervention not reported

Immediate change in level in year 2000 (noise level at work as PEL dose in dB(A); range 0 to 6400, log scale) · workers with noise exposure
1 finding from 1 review