Cochrane · systematic review · CD012611
Preventive lipid‐based nutrient supplements given with complementary foods to infants and young children 6 to 23 months of age for health, nutrition, and developmental outcomes
Das, JK, Salam, RA, Hadi, YB, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
27
current version
GRADE rated
18
No studies
9
Included studies
NR
No studies 9 · 33.3%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 14.8%Moderate 14 · 51.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: children aged 6 to 23 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stunting | no estimate extracted | NR | No studies |
Moderate stunting Measured as height‐for‐age z score < −2 SD Measured at 12, 18 and 24 months of age | RR 0.93 [0.88, 0.98] | 9 studies · 13372 participants | Moderate Downgraded: risk of bias, imprecision |
Severe stunting Measured as height‐for‐age z score < −3 SD Measured at 12, 18 and 24 months of age | RR 0.85 [0.74, 0.98] | 5 studies · 6151 participants | Moderate Downgraded: risk of bias, imprecision |
Wasting | no estimate extracted | NR | No studies |
Moderate wasting Measured as weight‐for‐height z score < −2 SD Measured at 12, 18 and 24 months of age | RR 0.82 [0.74, 0.91] | 8 studies · 13172 participants | Moderate Downgraded: risk of bias, imprecision |
Severe wasting Measured as weight‐for‐height z score < −3 SD Measured at 12 and 18 months of age | RR 1.27 [0.66, 2.46] | 3 studies · 2329 participants | Moderate Downgraded: inconsistency |
Underweight | no estimate extracted | NR | No studies |
Moderate underweight Measured as weight‐for‐age z score < −2 SD Measured at 12, 18 and 24 months of age | RR 0.85 [0.8, 0.91] | 8 studies · 13073 participants | Moderate Downgraded: risk of bias, imprecision |
Severe underweight Measured as weight‐for‐age z score < −3 SD Measured at 12 and 18 months of age | RR 0.78 [0.54, 1.13] | 2 studies · 1729 participants | Moderate Downgraded: inconsistency |
Anaemia Measured as haemoglobin < 10 g/dL Measured at 12, 18 and 24 months of age | RR 0.79 [0.69, 0.9] | 5 studies · 2332 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects Defined as deaths, hospitalisations, congenital abnormalities and life‐threatening conditions requiring an immediate hospital visit Assessed at 12 and 18 months of age | RR 0.86 [0.74, 1.01] | 3 studies · 3382 participants | Moderate Downgraded: risk of bias, imprecision |
Comparison
Population: children aged 6 to 23 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Stunting | no estimate extracted | NR | No studies |
Moderate stunting Measured as height‐for‐age z score < −2 SD Measured at 12 months and 18 months of age | RR 0.89 [0.82, 0.97] | 3 studies · 2828 participants | Moderate Downgraded: risk of bias |
Severe stunting Measured as height‐for‐age z score < −3 SD Measured at 12 months and 18 months of age | RR 0.41 [0.12, 1.42] | 2 studies · 729 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Wasting | no estimate extracted | NR | No studies |
Moderate wasting Measured as weight‐for‐height z score < −2 SD Measured at 12 months and 18 months of age | RR 0.79 [0.65, 0.97] | 2 studies · 2290 participants | Moderate Downgraded: risk of bias |
Severe wasting Measured as weight‐for‐height z score < −3 SD Measured at 12 months and 18 months of age | RR 0.64 [0.19, 2.18] | 2 studies · 735 participants | Moderate Downgraded: risk of bias |
Underweight | no estimate extracted | NR | No studies |
Moderate underweight Measured as weight‐for‐age z score < −2 SD Measured at 12 months and 18 months of age | RR 0.81 [0.73, 0.91] | 2 studies · 2280 participants | Moderate Downgraded: risk of bias |
Severe underweight Measured as weight‐for‐age z score < −3 SD Measured at 12 months of age | RR 1.23 [0.67, 2.25] | 1 study · 173 participants | Low Downgraded: risk of bias, imprecision |
Anaemia | no estimate extracted | NR | No studies |
Adverse effects | no estimate extracted | NR | No studies |
Comparison
Population: children aged 6 to 23 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Moderate stunting Measured as height‐for‐age z score < −2 SD Measured at 12 months and 24 months of age | RR 0.92 [0.82, 1.02] | 3 studies · 2365 participants | Moderate Downgraded: risk of bias |
Moderate wasting Measured as weight‐for‐height z score < −2 SD Measured at 12 months and 24 months of age | RR 0.97 [0.77, 1.23] | 2 studies · 2004 participants | Moderate Downgraded: risk of bias |
Moderate underweight Measured as weight‐for‐age z score < −2 SD Measured at 12 months and 24 months of age | RR 0.88 [0.78, 0.99] | 2 studies · 2004 participants | Moderate Downgraded: risk of bias |
Anaemia Measured as haemoglobin < 10 g/dL Measured at 12 months of age | RR 0.38 [0.21, 0.68] | 2 studies · 557 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects | no estimate extracted | NR | No studies |