Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,266 questions · 1,314 findings · 160 reviews · Headline outcomes only

No studies found 309 · 23.5%GRADE not reported 34 · 2.6%Very low 356 · 27.1%Low 393 · 29.9%Moderate 187 · 14.2%High 35 · 2.7%

School injury prevention programmes vs controls

Self‐reported medically or non‐medically attended unintentional injuries or injuries with an unspecified intent (injury rates adjusted for clustering) · children and young people aged 0 to 18 years

School injury prevention programmes showed no clear difference in self‐reported medically or non‐medically attended unintentional… compared with controls (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of pelvic inflammatory disease (PID) at 12 months (intention‐to‐treat) Outcome was clinically diagnosed PID reported by the participant or extracted from medical records, pharmacy records or hospital discharge coding. Outcome very likely... · healthy adults

The intervention probably leads to lower incidence of pelvic inflammatory disease (PID) at 12 months… (moderate certainty).

1 finding from 1 review

Therapeutic swallowing exercises vs treatment

Adverse event: Weight change Patient's body weight 6 months before the start of treatment was retrieved from the patient's medical notes and "relative weight change" was calculated as the percentage weight change relative to the weight at week 0 6... · adults with advanced head and neck cancer

It is very uncertain whether therapeutic swallowing exercises changes adverse event: Weight change Patient's body weight 6 months before… compared with treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Changes of fatigue scores from baseline to after treatment (assessed by energy/fatigue scale from the Medical Outcomes Study) · people with stroke not necessarily having fatigue
1 finding from 1 review

Intervention not reported

Neonatal mortality in all resuscitation episodes Medical records (resuscitation observation sheet) · nurses and midwives

The intervention showed no clear difference in neonatal mortality in all resuscitation episodes Medical records… (low certainty).

1 finding from 1 review

Tranexamic acid vs placebo/no treatment

Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

Self‐reported injuries or medically‐attended injuries · cyclists

The review found no eligible studies for this question.

1 finding from 1 review

Anticonvulsant vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with alcohol dependence

Anticonvulsants showed no clear difference in adverse events—withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Eculizumab vs placebo

Adverse events (serious and nonserious) Medical Dictionary for Regulatory Activities (MedDRA) · patients with paroxysmal nocturnal hemoglobinuria

Eculizumab showed no clear difference in adverse events (serious and nonserious) Medical Dictionary for… compared with placebo (low certainty).

1 finding from 1 review

Parenting interventions vs usual care

Medically attended or self‐reported injuries ‐ RCTs only · parents of children between the ages of 0 and 18 years

Parenting interventions probably leads to lower medically attended or self‐reported injuries ‐ RCTs only compared with usual care (moderate certainty).

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Health outcome (Number who had a medical complication of pelvic inflammatory disease) · patients taking prescribed and over‐the‐counter medications or their carers

Summary of findings: multimedia education and a co‐intervention showed no clear difference in health outcome (Number who had a medical complication of pelvic… compared with co‐intervention alone (low certainty).

1 finding from 1 review

Intervention not reported

Greatest crash reductions in areas within 2km of camera sites, with 31% (1100), 39% (2200), 19% (500) and 21% (1600) reductions estimated for hospitalisation, medically treated, other injury and non‐injury crashes respectively.
1 finding from 1 review