Cochrane · systematic review · CD007872
Tranexamic acid for preventing postpartum haemorrhage
Novikova, N, Hofmeyr, GJ, Cluver, C · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tranexamic acid versus placebo/no treatment for preventing postpartum haemorrhage
Population: pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood loss > 400 mL or > 500 mL Tranexamic acid vs placebo/no treatment | RR 0.52 [0.42, 0.63] | 6 studies · 1398 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Blood loss > 1000 mL Tranexamic acid vs placebo/no treatment | RR 0.4 [0.23, 0.71] | 6 studies · 2093 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Mean blood loss (mL) Tranexamic acid vs placebo/no treatment | no estimate extracted | 5 studies · 1186 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Use of additional medical interventions to control PPH Tranexamic acid vs placebo/no treatment | RR 0.48 [0.34, 0.68] | 5 studies · 2049 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Maternal death or severe maternal morbidity such as seizure, thromboembolic events, need for intensive care unit admission, hysterectomy, organ failure Tranexamic acid vs placebo/no treatment | no estimate extracted | 4 studies · 1511 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Side effects Tranexamic acid vs placebo/no treatment | RR 2.48 [1.36, 4.5] | 8 studies · 2616 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Thromboembolic events Tranexamic acid vs placebo/no treatment | RR 0.98 [0.14, 6.78] | 11 studies · 3012 participants | Low Downgraded: risk of bias, imprecision, inconsistency |