Cochrane · systematic review · CD010340
Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria
Martí‐Carvajal, AJ, Anand, V, Cardona, AF, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 0 · 0%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Eculizumab compared with placebo for paroxysmal nocturnal hemoglobinuria
Population: patients with paroxysmal nocturnal hemoglobinuria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival ‐ not measured Eculizumab vs placebo | no estimate extracted | 1 study · 87 participants | Ungraded |
All‐cause mortality Eculizumab vs placebo | no estimate extracted | 1 study · 87 participants | Ungraded |
Health‐related quality of life European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ‐C30). Scale from: 0 to 100 (a higher score means a better outcome) Eculizumab vs placebo | no estimate extracted | 1 study · 87 participants | Low Downgraded: risk of bias, imprecision |
Fatigue Functional Assessment of Chronic Illness Therapy‐Fatigue (FACIT‐Fatigue). Scale from: 0 to 52 (a higher score means a better outcome) Eculizumab vs placebo | no estimate extracted | 1 study · 87 participants | Moderate Downgraded: risk of bias |
Adverse events (serious and nonserious) Medical Dictionary for Regulatory Activities (MedDRA) Eculizumab vs placebo | RR 0.45 [0.15, 1.37] | 1 study · 87 participants | Low Downgraded: imprecision |
Transfusion independence Eculizumab vs placebo | RR 46.02 [2.88, 735.53] | 1 study · 87 participants | Moderate Downgraded: imprecision |
Withdrawal for any reason Eculizumab vs placebo | RR 0.2 [0.05, 0.88] | 1 study · 87 participants | Moderate Downgraded: imprecision |