Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced some plaque-related indices versus placebo, with low-certainty evidence.
1 finding from 1 review
Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Short-term fluoride mouthwash reduced Mutans streptococci, but certainty is very low.
2 findings from 1 review
Probing pocket depth (PPD/PD) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash may reduce pocket probing depth versus placebo in the short term (low certainty).
1 finding from 1 review
White spot lesion incidence · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
Most studies reported a lower incidence of white spot lesions with clear aligners than fixed appliances, but heterogeneous assessment methods precluded meta-analysis (ungraded).
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 13% incidence in teeth with pre-operative caries fillings or crowns.
2 findings from 1 review
Proportion 13
1 study
GRADE not reported
Proportion 5
1 study
GRADE not reported
Periapical pathosis incidence · Vital teeth
One study reported a 1.4% incidence with bone level < 35%.
2 findings from 1 review
Proportion 1.4
1 study
GRADE not reported
Proportion 0
1 study
GRADE not reported
Oral health-related quality of life · Indians
In adolescents (10-19 years), dental caries was associated with poorer OHRQoL (pooled OR 3.92; 5 studies); ungraded.
5 findings from 1 review
Show 2 more findings
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration did not differ significantly from P11-4 alone (SMD -0.39, 95% CI -0.97 to 0.20); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
Over 2 or more years in deciduous teeth, GIC probably had a higher risk of secondary caries than RMGIC (RR 1.92, 95% CI 1.03-3.56; moderate certainty).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with eugenol-based temporary cement was 3.34%.
2 findings from 1 review
Proportion 3.34 [1.66, 5.58]
7043 participants
GRADE not reported
Proportion 5.77 [3.72, 8.24]
639 participants
GRADE not reported
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, the effect of compomer versus GIC on secondary caries is very uncertain (RR 3.20, 95% CI 0.59-17.33; very low certainty).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
In deciduous teeth at 1 year, pooled bioactive materials (RMGIC and compomer) showed no significant difference from resin composite in secondary caries (RR 0.54, 95% CI 0.07-4.10; ungraded).
1 finding from 1 review
Dentin bridge formation · Patients with carious pulp exposure in permanent teeth undergoing partial pulpotomy
Evidence on dentin bridge formation for calcium hydroxide versus MTA is weak and imprecise, with no material shown superior (4 RCTs, not pooled; ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth
In immature teeth, the effect of MTA versus calcium hydroxide on success is very uncertain (OR 2.22, 95% CI 0.13-36.67; very low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing direct pulp capping
For direct pulp capping, MTA probably achieves higher clinical and radiographic success than calcium hydroxide (OR 3.10, 95% CI 1.66-5.79; moderate certainty).
1 finding from 1 review
Self-reported thirst · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
Gum chewing reduced self-reported thirst in most studies (6 of 7 positive, 1 no effect); not meta-analyzed.
1 finding from 1 review
Plaque · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash may reduce the Plaque Index versus blank control in the short term (WMD -0.70, 95% CI -1.12 to -0.27), but the evidence is very uncertain (very low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian adults and elderly (general, police, teachers, institutionalised)
No difference in OHRQoL was seen between groups for periodontal disease by LOA on OHIP-14/OIDP (pooled SMD -0.04, CI includes 0); ungraded.
3 findings from 1 review
SMD -0.04 [-2.01, 1.92]
4 studies · 3414 participants
Very low
Periodontal disease (LOA) and QoL (continuous, GOHAI): one study reported a significant negative impact (Rekhi 2016), one found no significant association (Marya 2020). Not pooled.
2 studies
GRADE not reported
Periodontal disease (LOA) and QoL (dichotomous): two studies found a significant association (Saxena 2018, Abhishek 2016), one denied it (Nagarajappa 2015, P=0.687). Not pooled.
3 studies
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Indians
Results were inconsistent and certainty was very low.
1 finding from 1 review
Plaque · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
CPC mouthwash may reduce plaque-related indexes versus blank control in the short term, but the evidence is very uncertain (very low certainty).
1 finding from 1 review