Question · asked by 1 review
Cetylpyridinium chloride mouthwash vs Blank control: Plaque
- Population
- Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
- Intervention
- Cetylpyridinium chloride mouthwash
- Comparison
- Blank control
- Outcome
- Plaque
CPC mouthwash may reduce plaque-related indexes versus blank control in the short term, but the evidence is very uncertain (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Cetylpyridinium chloride (CPC) mouthwash vs Blank control (no mouthwash; before-after comparison) Plaque-related index · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances) · <=3 months (short-term), Orthodontic patients undergoing orthodontic treatment (randomized controlled trials; multiple countries) CPC mouthwash may reduce plaque-related indexes versus blank control in the short term, but the evidence is very uncertain (very low certainty). The efficacy of mouthwashes on oral microorganisms and gingivitis in patients undergoing orthodontic… (2023) All outcomes | BBPI was significantly reduced compared to blank control [47]. PI was significantly reduced compared to blank control [50]. The amount of dental plaque was significantly reduced compared to baseline [38]. | 3 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The efficacy of mouthwashes on oral microorganisms and gingivitis in patients undergoing orthodontic treatment: a systematic review and… 2023 All outcomes | 16 April 2022 (databases and grey literature searched by 16 April 2022; no publication-year limit) | 47 | Low / Moderate |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.