Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Intervention not reported

Next‐day alertness Participant reports. Scale from: 0 to 10 points; higher scores equalled better outcome; CFB and double‐blind average values included · Patients with insomnia
1 finding from 1 review

Transfusion of RBCs of shorter vs longer storage duration

Mortality: in‐hospital mortality (within 7 days) · all conditions

It is very uncertain whether transfusion of RBCs of shorter changes mortality: in‐hospital mortality (within 7 days) compared with longer storage duration (very low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: short‐term mortality (up to 30 days) ‐ neonates · all conditions

It is very uncertain whether transfusion of RBCs of shorter changes mortality: short‐term mortality (up to 30 days) ‐ neonates compared with standard practice storage duration (very low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: short‐term mortality (up to 30 days) ‐ adults · all conditions

Transfusion of RBCs of shorter showed no clear difference in mortality: short‐term mortality (up to 30 days) ‐ adults compared with standard practice storage duration (moderate certainty).

1 finding from 1 review

Bispectral index vs treatment guided by clinical assessment alone?

Duration of mechanical ventilation · Mechanically ventilated adults in the intensive care unit

BIS monitoring showed no clear difference in duration of mechanical ventilation (measured in days) compared with clinical assessment (low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

AKI within 30 days of surgery · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes AKI within 30 days of surgery compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

RRT within 30 days of surgery · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes RRT within 30 days of surgery compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Postoperative delirium (POD) within 7 days (As assessed by any method such as the Mini‐Mental State Examination (MMSE) and Confusion Assessment Method (CAM) in the first week after operation) · adults aged 18 years or over undergoing general anaesthesia for non‐cardiac or non‐neurosurgical elective operations

The intervention probably leads to lower postoperative delirium (POD) within 7 days (As assessed by any… (moderate certainty).

1 finding from 1 review