Cochrane · systematic review · CD011274
Effects of peri‐operative nonsteroidal anti‐inflammatory drugs on post‐operative kidney function for adults with normal kidney function
Bell, S, Rennie, T, Marwick, CA, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 80%Low 1 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nonsteroidal anti‐inflammatory drugs (NSAIDs) versus placebo or no treatment in the peri‐operative period
Population: adults with normal kidney function undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AKI within 30 days of surgery Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs placebo or no treatment | RR 1.79 [0.4, 7.96] | 2 studies · 7066 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
SCr increase within 30 days of surgery Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs placebo or no treatment | no estimate extracted | 15 studies · 794 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
RRT within 30 days of surgery Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs placebo or no treatment | RR 1.57 [0.49, 5.07] | 2 studies · 7056 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Death (all causes) Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs placebo or no treatment | RR 1.44 [0.19, 11.12] | 2 studies · 312 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Length of hospital stay Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs placebo or no treatment | MD 0.12 | 3 studies · 410 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |