Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

34 questions · 35 findings · 14 reviews · Headline outcomes only

No studies found 6 · 17.1%GRADE not reported 1 · 2.9%Very low 15 · 42.9%Low 13 · 37.1%Moderate 0 · 0%High 0 · 0%

Prefabricated foot orthoses vs shoes

Withdrawals due to adverse events · children with juvenile idiopathic arthritis and flat feet

Prefabricated foot orthoses showed no clear difference in withdrawal due to adverse events compared with shoes; GRADE not reported.

1 finding from 1 review

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Withdrawals due to adverse events · people with chronic gout

Skim milk enriched with GMP/G600 showed no clear difference in study withdrawals due to adverse events compared with skim milk, plus lactose powder (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Antihypertensive drug therapy vs placebo or no treatment

Withdrawals due to adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes withdrawal due to adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Custom foot orthoses vs shoes

Withdrawals due to adverse events · children with juvenile idiopathic arthritis and flat feet

Custom foot orthoses showed no clear difference in withdrawal due to adverse events compared with shoes (low certainty).

1 finding from 1 review

Benzbromarone vs probenecid

Withdrawals due to adverse events · people with chronic gout

Benzbromarone may leads to lower withdrawal due to adverse events compared with probenecid (low certainty).

1 finding from 1 review

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review