Cochrane · systematic review · CD008920
Antidepressants for pain management in rheumatoid arthritis
Richards, BL, Whittle, SL, Buchbinder, R · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 83.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tricyclic antidepressant compared to control for pain management in RA
Population: patients with pain management in RA
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain < 1 week VAS scale 0 to 100 mm Tricyclic antidepressant vs control | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Pain 1 to 6 weeks Any pain measurement scale Tricyclic antidepressant vs control | no estimate extracted | 7 studies · 482 participants | Very low Downgraded: risk of bias, imprecision |
Pain > 6 weeks Any pain measurement scale Tricyclic antidepressant vs control | no estimate extracted | 5 studies · 368 participants | Very low Downgraded: risk of bias, imprecision |
Functional Status Health Assessment Questionnaire (HAQ) scale 0 to 3 Tricyclic antidepressant vs control | no estimate extracted | 1 study · 28 participants | Low Downgraded: risk of bias, imprecision |
Number of Withdrawals due to Adverse Events patient interview Tricyclic antidepressant vs control | RR 0.98 [0.59, 1.64] | 6 studies · 455 participants | Very low Downgraded: risk of bias, imprecision |
Total number of adverse events patient interview Tricyclic antidepressant vs control | RR 1.83 [1.01, 3.3] | 6 studies · 455 participants | Very low Downgraded: risk of bias, imprecision |