Treatment withdrawal · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide probably leads to higher treatment withdrawal compared with placebo (moderate certainty).
1 finding from 1 review
Treatment withdrawal · lung transplant recipients
Tacrolimus may leads to lower treatment withdrawal the number of patients stopping the assigned… compared with cyclosporin (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with drug‐resistant focal epilepsy
It is very uncertain whether carisbamate changes treatment withdrawal due to adverse events compared with placebo (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with drug‐resistant epilepsy
1 finding from 1 review
Treatment withdrawal · patients with drug‐resistant epilepsy
Flunarizine probably leads to higher treatment withdrawal Number of withdrawals compared with placebo (moderate certainty).
1 finding from 1 review
Treatment withdrawal · patients with drug‐resistant epilepsy
Nimodipine showed no clear difference in treatment withdrawal Number of withdrawals compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · people (aged 12 years and over) with drug‐resistant focal epilepsy
Perampanel add‐on may leads to higher treatment withdrawal due to adverse effects compared with placebo (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with drug‐resistant focal epilepsy
Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with drug‐resistant focal epilepsy
Brivaracetam may leads to higher proportion of participants who experienced adverse events leading to… compared with placebo (low certainty).
1 finding from 1 review
Treatment withdrawal for any reason Duration of treatment (range): 12 (3 months) to 36 weeks · people (aged 10–64 years) with drug‐resistant focal epilepsy
It is very uncertain whether vigabatrin changes treatment withdrawal for any reason Duration of treatment (range):… compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects (side effects; treatment withdrawals) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Johnson 1993 (5 mg tds): sweating 37%, headache 15%, urinary frequency 14%, vasodilatation 12%, dizziness 10%, dyspepsia 10%, nausea 8%, asthenia 8%, diarrhoea 5%; 6% withdrew at 5 mg tds and 29% at 10 mg tds. LeVeque…
2 studies · 278 participants
GRADE not reported
Adverse effects (side effects; treatment withdrawals) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Davies 1994: main side effects with pilocarpine were nausea 20%, sweating 15%, lacrimation 10%. One participant definitely withdrew because of side effects; another may have.
1 study · 20 participants
GRADE not reported
Withdrawals due to adverse events · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater
It is very uncertain whether evening changes withdrawals from treatment due to adverse events compared with morning dosing regimen (very low certainty).
1 finding from 1 review
Intervention not reported
Number of withdrawals (occurring between 4 and 10 weeks of onset of treatment) · children and adolescents with depression
The intervention showed no clear difference in number of withdrawals (occurring between 4 and 10 weeks of onset of… (low certainty).
1 finding from 1 review