Cochrane · systematic review · CD010961
Perampanel add‐on for drug‐resistant focal epilepsy
Bresnahan, R, Hill, RA, Wang, J · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 0 · 0%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Perampanel add‐on versus placebo for drug‐resistant focal epilepsy
Population: people (aged 12 years and over) with drug‐resistant focal epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
≥ 50% reduction in seizure frequency Perampanel add‐on vs placebo | RR 1.67 [1.43, 1.95] | 7 studies · 2524 participants | High |
Seizure freedom Perampanel add‐on vs placebo | RR 2.5 [1.38, 4.54] | 5 studies · 2323 participants | Low Downgraded: imprecision |
Treatment withdrawal due to any reason Perampanel add‐on vs placebo | RR 1.3 [1.03, 1.63] | 7 studies · 2524 participants | Low Downgraded: imprecision, inconsistency |
Treatment withdrawal due to adverse effects Perampanel add‐on vs placebo | RR 2.36 [1.59, 3.51] | 7 studies · 2524 participants | Low Downgraded: imprecision, inconsistency |
Proportion of participants who experienced ≥ 1 adverse effect Perampanel add‐on vs placebo | RR 1.17 [1.1, 1.24] | 7 studies · 2524 participants | High |
Proportion of participants who experienced ataxia Perampanel add‐on vs placebo | RR 14.32 | 2 studies · 1098 participants | Low Downgraded: imprecision |
Proportion of participants who experienced dizziness Perampanel add‐on vs placebo | RR 2.87 | 7 studies · 2524 participants | Low Downgraded: inconsistency |